biostudies-literatureUnknown4(5)Costentin C<h4>Background & aims</h4>Patients with hepatocellular carcinoma (HCC) are selected for liver transplantation (LT) based on pre-LT imaging ± alpha-foetoprotein (AFP) level, but discrepancies between pre-LT tumour assessment and explant are frequent. Our aim was to design an explant-based recurrence risk reassessment score to refine prediction of recurrence after LT and provide a framework to guide post-LT management.<h4>Methods</h4>Adult patients who underwent transplantation between 2000 and 2018 for HCC in 47 centres were included. A prediction model for recurrence was developed using competing-risk regression analysis in a European training cohort (TC; n = 1,359) and tested in a Latin American validation cohort (VC; n=1,085).<h4>Results</h4>In the TC, 76.4% of patients with HCC met the JHEP reports : innovation in hepatology100445https://www.ebi.ac.uk/biostudies/studies/S-EPMC8961219biostudies-literatureR3-AFP score is a new composite tool to refine prediction of hepatocellular carcinoma recurrence after liver transplantation.PMC8961219Burra PMuscari FDharancy SValerio LChristophe MGambato MCillo UParente Garcia JHMagini GOlivier DPellicelli AFatima Boin ISBoin IFPinelli DMaraschio MBaccaro CVilatoba MBoudjema KDeledinghen VAltieri MPaul LJFrancoz CQuinones EEduard CDi Benedetto FSilva MMattera JColasanti MJonas SAnders MFagiuoli SColledan MPageaux GPGugenheim JRadenne SDirk YConti FHoussel-Debry PVitale ACristina de Ataide EVennarecci GGiannelli VDibenedetto FChagas ADecaens TEttorre GMFrench-Italian-Belgium and Latin American collaborative group for HCC and liver transplantationMenendez RCPodesta LGWoehl MLCostentin CCosta PVan Vlierberghe HDuque SHZerega AMagistri PSamuele IRoberto TDuvoux CNotarpaolo ACarrilho FDumortier JChiche LD'Ambrosio CRubinstein FMenendez JBernard PHVaron AJeroen DSalame EHardwigsen JBarbier LLaurent AZapata RGadano ACherqui DPeter MAbergel AMcCormack LPoniachik JVanlemmens CMunoz LHilleret MNDegroote HMiglioresi LChris VBachellier PDurand FJean DSoza APinero FScatton OJacques PLai QArufe DMarciano SMachaca MPfalseR3-AFP score is a new composite tool to refine prediction of hepatocellular carcinoma recurrence after liver transplantation.<h4>Background & aims</h4>Patients with hepatocellular carcinoma (HCC) are selected for liver transplantation (LT) based on pre-LT imaging ± alpha-foetoprotein (AFP) level, but discrepancies between pre-LT tumour assessment and explant are frequent. Our aim was to design an explant-based recurrence risk reassessment score to refine prediction of recurrence after LT and provide a framework to guide post-LT management.<h4>Methods</h4>Adult patients who underwent transplantation between 2000 and 2018 for HCC in 47 centres were included. A prediction model for recurrence was developed using competing-risk regression analysis in a European training cohort (TC; n = 1,359) and tested in a Latin American validation cohort (VC; n=1,085).<h4>Results</h4>In the TC, 76.4% of patients with HCC met the 2022-01-01T00:00:00Z2022 May2026-05-30T15:03:20.906Z2025-04-04T23:03:09.641ZS-EPMC89612193536052210.1016/j.jhepr.2022.100445