{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["18"],"submitter":["Dong H"],"pubmed_abstract":["A personalized medication regimen provides precise treatment for an individual and can be guided by pre-clinical drug screening. The economical and high-efficiency simulation of the liver tumor microenvironment (TME) in a drug-screening model has high value yet challenging to accomplish. Herein, we propose a simulation of the liver TME with suspended alginate-gelatin hydrogel capsules encapsulating patient-derived liver tumor multicellular clusters, and the culture of patient-derived tumor organoids(PDTOs) for personalized pre-clinical drug screening. The hydrogel capsule offers a 3D matrix environment with mechanical and biological properties similar to those of the liver <i>in vivo</i>. As a result, 18 of the 28 patient-derived multicellular clusters were successfully cultured as PDTOs. "],"journal":["Bioactive materials"],"pagination":["164-177"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8961426"],"repository":["biostudies-literature"],"pubmed_title":["Culture of patient-derived multicellular clusters in suspended hydrogel capsules for pre-clinical personalized drug screening."],"pmcid":["PMC8961426"],"pubmed_authors":["Yang X","Bian S","Li Z","Song P","Dong H","Xie H","Li T","Zheng S","Zhang M","Song G","Song W"],"additional_accession":[]},"is_claimable":false,"name":"Culture of patient-derived multicellular clusters in suspended hydrogel capsules for pre-clinical personalized drug screening.","description":"A personalized medication regimen provides precise treatment for an individual and can be guided by pre-clinical drug screening. The economical and high-efficiency simulation of the liver tumor microenvironment (TME) in a drug-screening model has high value yet challenging to accomplish. Herein, we propose a simulation of the liver TME with suspended alginate-gelatin hydrogel capsules encapsulating patient-derived liver tumor multicellular clusters, and the culture of patient-derived tumor organoids(PDTOs) for personalized pre-clinical drug screening. The hydrogel capsule offers a 3D matrix environment with mechanical and biological properties similar to those of the liver <i>in vivo</i>. As a result, 18 of the 28 patient-derived multicellular clusters were successfully cultured as PDTOs. ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-04T23:16:36.877Z","creation":"2025-04-04T23:16:36.877Z"},"accession":"S-EPMC8961426","cross_references":{"pubmed":["35387168"],"doi":["10.1016/j.bioactmat.2022.03.020"]}}