{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16(5)"],"submitter":["Nadasdi A"],"funding":["Ramgen Plc."],"pubmed_abstract":["<b>Aim:</b> To investigate the serum circulating DPP4 activity in patients with COVID-19 disease. <b>Materials & methods:</b> Serum samples from 102 hospitalized COVID-19 patients and 43 post-COVID-19 plasma donors and 39 SARS-CoV-2 naive controls and their medical data were used. Circulating DPP4 activities according to different COVID-19 disease peak severity (WHO) groups at sampling and at peak were assessed. <b>Results:</b> A significant decrease (p < 0.0001) in serum DPP4 activity was found in study groups of higher disease severity. When the circulating DPP4 activity was assessed as a prognostic marker, the logistic regression (p = 0.0023) indicated that the enzyme activity is a predictor of mortality (median 9.5 days before death) with receiver operating characteristic area under th"],"journal":["Biomarkers in medicine"],"pagination":["317-330"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8961475"],"repository":["biostudies-literature"],"pubmed_title":["Decreased circulating dipeptidyl peptidase-4 enzyme activity is prognostic for severe outcomes in COVID-19 inpatients."],"pmcid":["PMC8961475"],"pubmed_authors":["Firneisz G","Ferdinandy P","Forhecz Z","Cseh G","Prohaszka ZZ","Reti M","Merkely B","Prohaszka Z","Nadasdi A","Sinkovits G","Arato M","Valyi-Nagy I","Lakatos B","Masszi T","Bobek I"],"additional_accession":[]},"is_claimable":false,"name":"Decreased circulating dipeptidyl peptidase-4 enzyme activity is prognostic for severe outcomes in COVID-19 inpatients.","description":"<b>Aim:</b> To investigate the serum circulating DPP4 activity in patients with COVID-19 disease. <b>Materials & methods:</b> Serum samples from 102 hospitalized COVID-19 patients and 43 post-COVID-19 plasma donors and 39 SARS-CoV-2 naive controls and their medical data were used. Circulating DPP4 activities according to different COVID-19 disease peak severity (WHO) groups at sampling and at peak were assessed. <b>Results:</b> A significant decrease (p < 0.0001) in serum DPP4 activity was found in study groups of higher disease severity. When the circulating DPP4 activity was assessed as a prognostic marker, the logistic regression (p = 0.0023) indicated that the enzyme activity is a predictor of mortality (median 9.5 days before death) with receiver operating characteristic area under th","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2026-05-31T18:01:04.299Z","creation":"2025-04-05T22:21:18.16Z"},"accession":"S-EPMC8961475","cross_references":{"pubmed":["35195023"],"doi":["10.2217/bmm-2021-0717"]}}