biostudies-literatureUnknown12(16)Naresh P<i>Background</i>: A novel strategy such as conjugation of amino, Schiff's bases, and thiadiazole moieties to the cinnamic acid nucleus has been adopted in this study to discover new molecules that target the dengue envelope protein (DENVE). <i>Aim</i>: Among the different domains of dengue virus envelope protein (PDB ID 1OKE), we have selected a ligand-binding domain for our structure-based drug design. The designed compounds have also been docked against DENVE protein. <i>Methodology</i>: Based on the <i>in silico</i> results and synthetic feasibility, three different schemes were used to synthesize twenty-three novel cinnamic acid derivatives. Sci-finder ascertained their novelty. The synthesized derivatives were consistent with their assigned spectra. The compounds were further evaluatRSC advances9793-9814https://www.ebi.ac.uk/biostudies/studies/S-EPMC8961603biostudies-literatureLarvicidal and histopathological efficacy of cinnamic acid analogues: a novel strategy to reduce the dengue vector competence.PMC8961603Prabha TRajesh Kumar RRajagopal GVishwas HNJubie SNaresh PfalseLarvicidal and histopathological efficacy of cinnamic acid analogues: a novel strategy to reduce the dengue vector competence.<i>Background</i>: A novel strategy such as conjugation of amino, Schiff's bases, and thiadiazole moieties to the cinnamic acid nucleus has been adopted in this study to discover new molecules that target the dengue envelope protein (DENVE). <i>Aim</i>: Among the different domains of dengue virus envelope protein (PDB ID 1OKE), we have selected a ligand-binding domain for our structure-based drug design. The designed compounds have also been docked against DENVE protein. <i>Methodology</i>: Based on the <i>in silico</i> results and synthetic feasibility, three different schemes were used to synthesize twenty-three novel cinnamic acid derivatives. Sci-finder ascertained their novelty. The synthesized derivatives were consistent with their assigned spectra. The compounds were further evaluat2022-01-01T00:00:00Z2022 Mar2025-04-06T03:59:36.884Z2024-11-05T18:32:16.64ZS-EPMC89616033542492010.1039/d1ra09466a