{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Liang S"],"funding":["NHLBI NIH HHS","National Natural Science Foundation of China","National Institutes of Health grants","National Key Research and Development Program of China"],"pagination":["341"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8961787"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(2)"],"pubmed_abstract":["Pulmonary arterial hypertension (PAH) is a progressive disease characterized by elevated pulmonary arterial pressure due to increased pulmonary vascular resistance, secondary to sustained pulmonary vasoconstriction and excessive obliterative pulmonary vascular remodeling. Work over the last decade has led to the identification of a critical role for metabolic reprogramming in the PAH pathogenesis. It is becoming clear that in addition to its role in ATP generation, the mitochondrion is an important organelle that regulates complex and integrative metabolic- and signal transduction pathways. This review focuses on mitochondrial metabolism alterations that occur in deranged pulmonary vessels and the right ventricle, including abnormalities in glycolysis and glucose oxidation, fatty acid oxid"],"journal":["Biomedicines"],"pubmed_title":["Mitochondrial Metabolism, Redox, and Calcium Homeostasis in Pulmonary Arterial Hypertension."],"pmcid":["PMC8961787"],"funding_grant_id":["81970052, 81770059 and 82170057","P01 HL146369","P01HL134610 and P01HL146369","2019YFE0119400"],"pubmed_authors":["Liang S","Yegambaram M","Black SM","Wang T","Wang J","Tang H"],"additional_accession":[]},"is_claimable":false,"name":"Mitochondrial Metabolism, Redox, and Calcium Homeostasis in Pulmonary Arterial Hypertension.","description":"Pulmonary arterial hypertension (PAH) is a progressive disease characterized by elevated pulmonary arterial pressure due to increased pulmonary vascular resistance, secondary to sustained pulmonary vasoconstriction and excessive obliterative pulmonary vascular remodeling. Work over the last decade has led to the identification of a critical role for metabolic reprogramming in the PAH pathogenesis. It is becoming clear that in addition to its role in ATP generation, the mitochondrion is an important organelle that regulates complex and integrative metabolic- and signal transduction pathways. This review focuses on mitochondrial metabolism alterations that occur in deranged pulmonary vessels and the right ventricle, including abnormalities in glycolysis and glucose oxidation, fatty acid oxid","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Feb","modification":"2025-04-22T09:49:43.154Z","creation":"2025-04-05T23:14:17.338Z"},"accession":"S-EPMC8961787","cross_references":{"pubmed":["35203550"],"doi":["10.3390/biomedicines10020341"]}}