{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lavios A"],"funding":["Ministerio de Educación y Cultura","Ministerio de Ciencia e Innovación","Seventh Framework Programme"],"pagination":["2149-2154"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8961877"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(11)"],"pubmed_abstract":["The diastereo- and enantioselective dearomative formal [3 + 2] cycloaddition of 2-nitrobenzofurans and α-aryl-α-isocyanoacetate esters provides tricyclic compounds bearing the 3<i>a</i>,8<i>b</i>-dihydro-1<i>H</i>-benzofuro[2,3-<i>c</i>]pyrrole framework with three consecutive stereogenic centers. The reaction was enabled by a cupreine-ether organocatalyst. The reaction products were obtained with almost full diastereoselectivity and with excellent enantiomeric excesses for a number of substituted 2-nitrobenzofurans and isocyanoacetates."],"journal":["Organic letters"],"pubmed_title":["Metal-Free Diastereo- and Enantioselective Dearomative Formal [3 + 2] Cycloaddition of 2-Nitrobenzofurans and Isocyanoacetate Esters."],"pmcid":["PMC8961877"],"funding_grant_id":["PID2020-116944GB-100","RyC-2016-20187","FPU18/03038","MCIN/AEI/ 10.13039/501100011033"],"pubmed_authors":["Lavios A","Vila C","Sanz-Marco A","Blay G","Munoz MC","Pedro JR"],"additional_accession":[]},"is_claimable":false,"name":"Metal-Free Diastereo- and Enantioselective Dearomative Formal [3 + 2] Cycloaddition of 2-Nitrobenzofurans and Isocyanoacetate Esters.","description":"The diastereo- and enantioselective dearomative formal [3 + 2] cycloaddition of 2-nitrobenzofurans and α-aryl-α-isocyanoacetate esters provides tricyclic compounds bearing the 3<i>a</i>,8<i>b</i>-dihydro-1<i>H</i>-benzofuro[2,3-<i>c</i>]pyrrole framework with three consecutive stereogenic centers. The reaction was enabled by a cupreine-ether organocatalyst. The reaction products were obtained with almost full diastereoselectivity and with excellent enantiomeric excesses for a number of substituted 2-nitrobenzofurans and isocyanoacetates.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-04-05T15:58:50.854Z","creation":"2025-04-05T15:58:50.854Z"},"accession":"S-EPMC8961877","cross_references":{"pubmed":["35293212"],"doi":["10.1021/acs.orglett.2c00427"]}}