{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhang Y"],"funding":["Key Technologies Research and Development Program","Department of Science and Technology of Sichuan Province"],"pagination":["165"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8961928"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["20(1)"],"pubmed_abstract":["<h4>Background</h4>Browning of white adipose tissue (WAT) is a particularly appealing target for therapeutics in the treatment of obesity and related metabolic diseases. Although small extracellular vesicles (sEVs) released from adipose tissue (sEVs-AT) have emerged as novel player that regulate systemic metabolism by connecting different organs, the role of specific contents in sEVs-AT played in WAT browning has not been clarified.<h4>Results</h4>We revealed Nucleophosmin3 (NPM3), which was mainly transferred by sEVs derived from brown adipose tissue (sEVs-BAT), was served as a batokine that could induce WAT browning by regulating the stability of PRDM16 mRNA. sEVs-BAT enhanced the expressions of browning related genes in 3T3-L1 preadipocytes and WAT while knocking down of NPM3 in BAT imp"],"journal":["Journal of nanobiotechnology"],"pubmed_title":["Nucleophosmin3 carried by small extracellular vesicles contribute to white adipose tissue browning."],"pmcid":["PMC8961928"],"funding_grant_id":["2017YFA0104800","2019YFS0312"],"pubmed_authors":["Yu M","Tian W","Zhang Y","Dong J","Wu Y"],"additional_accession":[]},"is_claimable":false,"name":"Nucleophosmin3 carried by small extracellular vesicles contribute to white adipose tissue browning.","description":"<h4>Background</h4>Browning of white adipose tissue (WAT) is a particularly appealing target for therapeutics in the treatment of obesity and related metabolic diseases. Although small extracellular vesicles (sEVs) released from adipose tissue (sEVs-AT) have emerged as novel player that regulate systemic metabolism by connecting different organs, the role of specific contents in sEVs-AT played in WAT browning has not been clarified.<h4>Results</h4>We revealed Nucleophosmin3 (NPM3), which was mainly transferred by sEVs derived from brown adipose tissue (sEVs-BAT), was served as a batokine that could induce WAT browning by regulating the stability of PRDM16 mRNA. sEVs-BAT enhanced the expressions of browning related genes in 3T3-L1 preadipocytes and WAT while knocking down of NPM3 in BAT imp","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-04-04T19:10:21.918Z","creation":"2025-04-04T19:10:21.918Z"},"accession":"S-EPMC8961928","cross_references":{"pubmed":["35346213"],"doi":["10.1186/s12951-022-01381-1"]}}