biostudies-literatureUnknown23(1)Lyman KS<h4>Background</h4>In a previous study, we assessed a novel, remotely monitored carbohydrate restricted diet regimen including nutritional ketosis in patients with type 2 diabetes and reported significant improvements in weight, glycemic control, abdominal fat and inflammation from baseline to 2 years. Knee outcome measures were collected as a secondary outcome in the trial. This study aims to assess the effect of this intervention on knee functional scores and to identify if changes in weight, central abdominal fat (CAF), glycemic status and high sensitivity C-reactive protein (hsCRP) were associated with its improvement.<h4>Methods</h4>This prospective analysis included continuous care intervention (CCI, n = 173) and usual care (UC, n = 69) trial participants with type 2 diabetes that reBMC musculoskeletal disorders297https://www.ebi.ac.uk/biostudies/studies/S-EPMC8961996biostudies-literatureContinuous care intervention with carbohydrate restriction improves physical function of the knees among patients with type 2 diabetes: a non-randomized study.PMC8961996Andrawis JPHallberg SJMcCarter JPVolek JSMcKenzie ALPhinney SDPearson CLAdams RNLyman KSAthinarayanan SJfalseContinuous care intervention with carbohydrate restriction improves physical function of the knees among patients with type 2 diabetes: a non-randomized study.<h4>Background</h4>In a previous study, we assessed a novel, remotely monitored carbohydrate restricted diet regimen including nutritional ketosis in patients with type 2 diabetes and reported significant improvements in weight, glycemic control, abdominal fat and inflammation from baseline to 2 years. Knee outcome measures were collected as a secondary outcome in the trial. This study aims to assess the effect of this intervention on knee functional scores and to identify if changes in weight, central abdominal fat (CAF), glycemic status and high sensitivity C-reactive protein (hsCRP) were associated with its improvement.<h4>Methods</h4>This prospective analysis included continuous care intervention (CCI, n = 173) and usual care (UC, n = 69) trial participants with type 2 diabetes that re2022-01-01T00:00:00Z2022 Mar2026-05-31T09:53:58.366Z2026-04-08T08:21:36.138ZS-EPMC89619963535109310.1186/s12891-022-05258-0