biostudies-literatureGil JInstituto de Salud Carlos IIINovartis (Spain)460https://www.ebi.ac.uk/biostudies/studies/S-EPMC8962441biostudies-literatureUnknown10(2)Acromegaly is caused by excess growth hormone (GH) produced by a pituitary tumor. First-generation somatostatin receptor ligands (SRLs) are the first-line treatment. Several studies have linked E-cadherin loss and epithelial-mesenchymal transition (EMT) with resistance to SRLs. Our aim was to study EMT and its relationship with SRLs resistance in GH-producing tumors. We analyzed the expression of EMT-related genes by RT-qPCR in 57 tumors. The postsurgical response to SRLs was categorized as complete response, partial response, or nonresponse if IGF-1 was normal, had decreased more than 30% without normalization, or neither of those, respectively. Most tumors showed a hybrid and variable EMT expression profile not specifically associated with SRL response instead of a defined epithelial or BiomedicinesImplications of Heterogeneity of Epithelial-Mesenchymal States in Acromegaly Therapeutic Pharmacologic Response.PMC8962441REMAHPMP 15/00027Rodriguez-Lloveras HLamas CHostalot CMarazuela MBernabeu ICamara RWebb SMFajardo-Montanana CSerra GGil JValassi EPuig-Domingo MSalinas IBiagetti BCarrato CMarques-Pamies MJorda MSimo-Servat AGarcia-Martinez APico AfalseImplications of Heterogeneity of Epithelial-Mesenchymal States in Acromegaly Therapeutic Pharmacologic Response.Acromegaly is caused by excess growth hormone (GH) produced by a pituitary tumor. First-generation somatostatin receptor ligands (SRLs) are the first-line treatment. Several studies have linked E-cadherin loss and epithelial-mesenchymal transition (EMT) with resistance to SRLs. Our aim was to study EMT and its relationship with SRLs resistance in GH-producing tumors. We analyzed the expression of EMT-related genes by RT-qPCR in 57 tumors. The postsurgical response to SRLs was categorized as complete response, partial response, or nonresponse if IGF-1 was normal, had decreased more than 30% without normalization, or neither of those, respectively. Most tumors showed a hybrid and variable EMT expression profile not specifically associated with SRL response instead of a defined epithelial or 2022-01-01T00:00:00Z2022 Feb2026-04-08T17:37:26.243Z2025-02-19T03:59:04.024ZS-EPMC89624413520366810.3390/biomedicines10020460