{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wei L"],"funding":["National Natural Science Foundation of China"],"pagination":["819274"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8962740"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9"],"pubmed_abstract":["<h4>Background</h4>Dyslipidemia and hypertension are two important independent risk factors for ischemic stroke (IS); however, their combined effect on IS remains uncertain.<h4>Objectives</h4>This present study aimed to evaluate the interaction effect of hypertension and abnormal lipid indices on IS in a 10-year prospective cohort in Chinese adults.<h4>Methods</h4>The cohort study of 4,128 participants was conducted in May 2009 and was followed up to July 2020. All qualified participants received a questionnaire survey, physical examination, and blood sample detection. Cox regression was used to evaluate the association of dyslipidemia and hypertension with IS, and calculate the hazard ratio (HR) and 95% confidence interval (CI). The relative excess risk of interaction (RERI) and the HR (9"],"journal":["Frontiers in cardiovascular medicine"],"pubmed_title":["Interaction Analysis of Abnormal Lipid Indices and Hypertension for Ischemic Stroke: A 10-Year Prospective Cohort Study."],"pmcid":["PMC8962740"],"funding_grant_id":["82173611","81573232","81872686"],"pubmed_authors":["Wei P","Xie H","Zhuang Q","Dong J","Chen Y","Shen C","Chen C","Yang S","Wei L","Sun J","Li M","Zhao X"],"additional_accession":[]},"is_claimable":false,"name":"Interaction Analysis of Abnormal Lipid Indices and Hypertension for Ischemic Stroke: A 10-Year Prospective Cohort Study.","description":"<h4>Background</h4>Dyslipidemia and hypertension are two important independent risk factors for ischemic stroke (IS); however, their combined effect on IS remains uncertain.<h4>Objectives</h4>This present study aimed to evaluate the interaction effect of hypertension and abnormal lipid indices on IS in a 10-year prospective cohort in Chinese adults.<h4>Methods</h4>The cohort study of 4,128 participants was conducted in May 2009 and was followed up to July 2020. All qualified participants received a questionnaire survey, physical examination, and blood sample detection. Cox regression was used to evaluate the association of dyslipidemia and hypertension with IS, and calculate the hazard ratio (HR) and 95% confidence interval (CI). The relative excess risk of interaction (RERI) and the HR (9","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-05T15:52:52.163Z","creation":"2025-04-05T15:52:52.163Z"},"accession":"S-EPMC8962740","cross_references":{"pubmed":["35360026"],"doi":["10.3389/fcvm.2022.819274"]}}