biostudies-literatureWei LNational Natural Science Foundation of China819274https://www.ebi.ac.uk/biostudies/studies/S-EPMC8962740biostudies-literatureUnknown9<h4>Background</h4>Dyslipidemia and hypertension are two important independent risk factors for ischemic stroke (IS); however, their combined effect on IS remains uncertain.<h4>Objectives</h4>This present study aimed to evaluate the interaction effect of hypertension and abnormal lipid indices on IS in a 10-year prospective cohort in Chinese adults.<h4>Methods</h4>The cohort study of 4,128 participants was conducted in May 2009 and was followed up to July 2020. All qualified participants received a questionnaire survey, physical examination, and blood sample detection. Cox regression was used to evaluate the association of dyslipidemia and hypertension with IS, and calculate the hazard ratio (HR) and 95% confidence interval (CI). The relative excess risk of interaction (RERI) and the HR (9Frontiers in cardiovascular medicineInteraction Analysis of Abnormal Lipid Indices and Hypertension for Ischemic Stroke: A 10-Year Prospective Cohort Study.PMC8962740821736118157323281872686Wei PXie HZhuang QDong JChen YShen CChen CYang SWei LSun JLi MZhao XfalseInteraction Analysis of Abnormal Lipid Indices and Hypertension for Ischemic Stroke: A 10-Year Prospective Cohort Study.<h4>Background</h4>Dyslipidemia and hypertension are two important independent risk factors for ischemic stroke (IS); however, their combined effect on IS remains uncertain.<h4>Objectives</h4>This present study aimed to evaluate the interaction effect of hypertension and abnormal lipid indices on IS in a 10-year prospective cohort in Chinese adults.<h4>Methods</h4>The cohort study of 4,128 participants was conducted in May 2009 and was followed up to July 2020. All qualified participants received a questionnaire survey, physical examination, and blood sample detection. Cox regression was used to evaluate the association of dyslipidemia and hypertension with IS, and calculate the hazard ratio (HR) and 95% confidence interval (CI). The relative excess risk of interaction (RERI) and the HR (92022-01-01T00:00:00Z20222025-04-05T15:52:52.163Z2025-04-05T15:52:52.163ZS-EPMC89627403536002610.3389/fcvm.2022.819274