biostudies-literatureGrome HNNIAID NIH HHSNIH HHS833-836https://www.ebi.ac.uk/biostudies/studies/S-EPMC8962897biostudies-literatureUnknown28(4)We report an outbreak of severe acute respiratory syndrome coronavirus 2 involving 3 Malayan tigers (Panthera tigris jacksoni) at a zoo in Tennessee, USA. Investigation identified naturally occurring tiger-to-tiger transmission; genetic sequence change occurred with viral passage. We provide epidemiologic, environmental, and genomic sequencing data for animal and human infections.Emerging infectious diseasesSARS-CoV-2 Outbreak among Malayan Tigers and Humans, Tennessee, USA, 2020.PMC8962897HHSN272201400008CMeyer BTong SUehara ASawatzki KBuchanan MQueen KThomas LSCushing ARead ELevinson KJGhai RPerry ZTao YDunn JGrome HNJones TFFill MMSchaffner WfalseSARS-CoV-2 Outbreak among Malayan Tigers and Humans, Tennessee, USA, 2020.We report an outbreak of severe acute respiratory syndrome coronavirus 2 involving 3 Malayan tigers (Panthera tigris jacksoni) at a zoo in Tennessee, USA. Investigation identified naturally occurring tiger-to-tiger transmission; genetic sequence change occurred with viral passage. We provide epidemiologic, environmental, and genomic sequencing data for animal and human infections.2022-01-01T00:00:00Z2022 Apr2025-04-26T13:01:27.461Z2025-04-06T14:07:16.075ZS-EPMC89628973531892210.3201/eid2804.212219