{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Zhao Y"],"pubmed_abstract":["Mitochondrial dysfunction could induce innate immune response with cytokines releasing to initiate Sjögren's syndrome (SS) onset. Single nucleotide polymorphisms (SNPs) in the mitochondrial displacement loop (D-loop) and mitochondrial DNA (mtDNA) copy number of female SS patients were evaluated for their association with SS in female patients. At the nucleotide site of 152, 16304, 16311 and 16362 in the D-loop, the frequencies for the minor alleles of 152C (<i>p</i> = 0.040, odds ratio [OR] = 0.504), 16304C (<i>p</i> = 0.045, OR = 0.406), 16311C (<i>p</i> = 0.045, OR = 0.406) and 16362C (<i>p</i> = 0.028, OR = 0.519) were significantly higher in the SS patients than those in the female controls, which indicated that 152,C, 16304C, 16311C, and 16362C allele in the D-loop of mtDNA were assoc"],"journal":["Frontiers in genetics"],"pagination":["847521"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8963357"],"repository":["biostudies-literature"],"pubmed_title":["Mitochondrial Displacement Loop Region SNPs Modify Sjogren's Syndrome Development by Regulating Cytokines Expression in Female Patients."],"pmcid":["PMC8963357"],"pubmed_authors":["Guo Z","Zhang J","Peng C","Zhang X","Lai R","Zhao Y"],"additional_accession":[]},"is_claimable":false,"name":"Mitochondrial Displacement Loop Region SNPs Modify Sjogren's Syndrome Development by Regulating Cytokines Expression in Female Patients.","description":"Mitochondrial dysfunction could induce innate immune response with cytokines releasing to initiate Sjögren's syndrome (SS) onset. Single nucleotide polymorphisms (SNPs) in the mitochondrial displacement loop (D-loop) and mitochondrial DNA (mtDNA) copy number of female SS patients were evaluated for their association with SS in female patients. At the nucleotide site of 152, 16304, 16311 and 16362 in the D-loop, the frequencies for the minor alleles of 152C (<i>p</i> = 0.040, odds ratio [OR] = 0.504), 16304C (<i>p</i> = 0.045, OR = 0.406), 16311C (<i>p</i> = 0.045, OR = 0.406) and 16362C (<i>p</i> = 0.028, OR = 0.519) were significantly higher in the SS patients than those in the female controls, which indicated that 152,C, 16304C, 16311C, and 16362C allele in the D-loop of mtDNA were assoc","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-05-18T12:06:42.117Z","creation":"2025-05-18T12:06:42.117Z"},"accession":"S-EPMC8963357","cross_references":{"pubmed":["35360865"],"doi":["10.3389/fgene.2022.847521"]}}