{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Lee JA"],"funding":["U.S. Department of Energy","National Science Foundation"],"pubmed_abstract":["Pink-pigmented facultative methylotrophs have long been studied for their ability to grow on reduced single-carbon (C<sub>1</sub>) compounds. The C<sub>1</sub> groups that support methylotrophic growth may come from a variety of sources. Here, we describe a group of <i>Methylobacterium</i> strains that can engage in methoxydotrophy: they can metabolize the methoxy groups from several aromatic compounds that are commonly the product of lignin depolymerization. Furthermore, these organisms can utilize the full aromatic ring as a growth substrate, a phenotype that has rarely been described in <i>Methylobacterium</i>. We demonstrated growth on <i>p</i>-hydroxybenzoate, protocatechuate, vanillate, and ferulate in laboratory culture conditions. We also used comparative genomics to explore the ev"],"journal":["Frontiers in microbiology"],"pagination":["849573"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8963497"],"repository":["biostudies-literature"],"pubmed_title":["Aerobic Methoxydotrophy: Growth on Methoxylated Aromatic Compounds by <i>Methylobacteriaceae</i>."],"pmcid":["PMC8963497"],"pubmed_authors":["Stolyar S","Lee JA","Marx CJ"],"additional_accession":[]},"is_claimable":false,"name":"Aerobic Methoxydotrophy: Growth on Methoxylated Aromatic Compounds by <i>Methylobacteriaceae</i>.","description":"Pink-pigmented facultative methylotrophs have long been studied for their ability to grow on reduced single-carbon (C<sub>1</sub>) compounds. The C<sub>1</sub> groups that support methylotrophic growth may come from a variety of sources. Here, we describe a group of <i>Methylobacterium</i> strains that can engage in methoxydotrophy: they can metabolize the methoxy groups from several aromatic compounds that are commonly the product of lignin depolymerization. Furthermore, these organisms can utilize the full aromatic ring as a growth substrate, a phenotype that has rarely been described in <i>Methylobacterium</i>. We demonstrated growth on <i>p</i>-hydroxybenzoate, protocatechuate, vanillate, and ferulate in laboratory culture conditions. We also used comparative genomics to explore the ev","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-04-08T18:07:45.83Z","creation":"2025-04-06T16:57:00.195Z"},"accession":"S-EPMC8963497","cross_references":{"pubmed":["35359736"],"doi":["10.3389/fmicb.2022.849573"]}}