biostudies-literatureUnknown11Pieralisi AVChronic Chagas disease cardiomyopathy (CCC) is the most important clinical manifestation of infection with <i>Trypanosma cruzi</i> (<i>T. cruzi</i>) due to its frequency and effects on morbidity and mortality. Peripheral blood mononuclear cells (PBMC) infiltrate the tissue and differentiate into inflammatory macrophages. Advances in pathophysiology show that myeloid cell subpopulations contribute to cardiac homeostasis, emerging as possible therapeutic targets. We previously demonstrated that fenofibrate, PPARα agonist, controls inflammation, prevents fibrosis and improves cardiac function in a murine infection model. In this work we investigated the spontaneous release of inflammatory cytokines and chemokines, changes in the frequencies of monocyte subsets, and fenofibrate effects on PBMCFrontiers in cellular and infection microbiology785166https://www.ebi.ac.uk/biostudies/studies/S-EPMC8963737biostudies-literatureFenofibrate Increases the Population of Non-Classical Monocytes in Asymptomatic Chagas Disease Patients and Modulates Inflammatory Cytokines in PBMC.PMC8963737Goren NBMirkin GAPrado NGagliardi JPenas FNCevey ACMori AGili MPieralisi AVfalseFenofibrate Increases the Population of Non-Classical Monocytes in Asymptomatic Chagas Disease Patients and Modulates Inflammatory Cytokines in PBMC.Chronic Chagas disease cardiomyopathy (CCC) is the most important clinical manifestation of infection with <i>Trypanosma cruzi</i> (<i>T. cruzi</i>) due to its frequency and effects on morbidity and mortality. Peripheral blood mononuclear cells (PBMC) infiltrate the tissue and differentiate into inflammatory macrophages. Advances in pathophysiology show that myeloid cell subpopulations contribute to cardiac homeostasis, emerging as possible therapeutic targets. We previously demonstrated that fenofibrate, PPARα agonist, controls inflammation, prevents fibrosis and improves cardiac function in a murine infection model. In this work we investigated the spontaneous release of inflammatory cytokines and chemokines, changes in the frequencies of monocyte subsets, and fenofibrate effects on PBMC2021-01-01T00:00:00Z20212025-04-05T14:43:02.629Z2025-04-05T14:43:02.629ZS-EPMC89637373536022210.3389/fcimb.2021.785166