{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["4(5)"],"submitter":["Pfeifer J"],"pubmed_abstract":["Background
Multisystem inflammatory syndrome in children (MIS-C) is a rare but serious complication of infection with SARS-CoV-2. A possible involvement of pathogenetically relevant autoantibodies has been discussed. Recently, neutralising autoantibodies against inflammatory receptor antagonists progranulin and interleukin-1 receptor antagonist (IL-1Ra) were found in adult patients with critical COVID-19. The aim of this study was to investigate the role of such autoantibodies in MIS-C.Methods
In this multicentre, retrospective, cohort study, plasma and serum samples were collected from patients (0-18 years) with MIS-C (as per WHO criteria) treated at five clinical centres in Germany and Spain. As controls, we included plasma or serum samples from children with Kawasaki dis"],"journal":["The Lancet. Rheumatology"],"pagination":["e329-e337"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8963770"],"repository":["biostudies-literature"],"pubmed_title":["Autoantibodies against interleukin-1 receptor antagonist in multisystem inflammatory syndrome in children: a multicentre, retrospective, cohort study."],"pmcid":["PMC8963770"],"pubmed_authors":["Keren A","Thurner B","Jakob A","Kheiroddin P","Gerling S","Abdul-Khaliq H","Wittkowski H","Detemple MC","Meyer S","Anton J","Regitz E","Sauer H","Lohse S","Birk E","Thurner L","Masjosthusmann K","Becker SL","Roemer K","Foell D","Kos IA","Heyne K","Preuss KD","Smola S","Bewarder M","Pfeifer J","Kessel C","Rohrer T","Fischer Y","Hoffmann MC","Fedlmeier M","Pino-Ramirez RM","Bals R","Kabesch M","Bohm M","Fadle N","Juenger H"],"additional_accession":[]},"is_claimable":false,"name":"Autoantibodies against interleukin-1 receptor antagonist in multisystem inflammatory syndrome in children: a multicentre, retrospective, cohort study.","description":"Background
Multisystem inflammatory syndrome in children (MIS-C) is a rare but serious complication of infection with SARS-CoV-2. A possible involvement of pathogenetically relevant autoantibodies has been discussed. Recently, neutralising autoantibodies against inflammatory receptor antagonists progranulin and interleukin-1 receptor antagonist (IL-1Ra) were found in adult patients with critical COVID-19. The aim of this study was to investigate the role of such autoantibodies in MIS-C.Methods
In this multicentre, retrospective, cohort study, plasma and serum samples were collected from patients (0-18 years) with MIS-C (as per WHO criteria) treated at five clinical centres in Germany and Spain. As controls, we included plasma or serum samples from children with Kawasaki dis","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 May","modification":"2025-06-01T01:33:42.005Z","creation":"2025-06-01T01:33:42.005Z"},"accession":"S-EPMC8963770","cross_references":{"pubmed":["35368387"],"doi":["10.1016/S2665-9913(22)00064-9"]}}