{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Bridoux M"],"pubmed_abstract":["<b>Background:</b> Proton pump inhibitors (PPIs) are one of the most widely used drugs worldwide and are overprescribed in patients with cancer; there is increasing evidence of their effects on cancer development and survival. The objective of this narrative review is to comprehensively identify cancer medications that have clinically meaningful drug-drug interactions (DDIs) with PPIs, including loss of efficacy or adverse effects, and to explore the association between PPIs and cancer. <b>Methods:</b> A PubMed search of English language studies published from 1 January 2016, to 1 June 2021 was conducted. The search terms included \"proton pump inhibitors,\" \"cancer,\" \"chemotherapy,\" \"immunotherapy,\" \"hormonotherapies,\" \"targeted therapies,\" \"tyrosine kinase inhibitors,\" and \"gut microbiome\""],"journal":["Frontiers in pharmacology"],"pagination":["798272"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8963837"],"repository":["biostudies-literature"],"pubmed_title":["Proton Pump Inhibitors and Cancer: Current State of Play."],"pmcid":["PMC8963837"],"pubmed_authors":["Simon N","Bridoux M","Turpin A"],"additional_accession":[]},"is_claimable":false,"name":"Proton Pump Inhibitors and Cancer: Current State of Play.","description":"<b>Background:</b> Proton pump inhibitors (PPIs) are one of the most widely used drugs worldwide and are overprescribed in patients with cancer; there is increasing evidence of their effects on cancer development and survival. The objective of this narrative review is to comprehensively identify cancer medications that have clinically meaningful drug-drug interactions (DDIs) with PPIs, including loss of efficacy or adverse effects, and to explore the association between PPIs and cancer. <b>Methods:</b> A PubMed search of English language studies published from 1 January 2016, to 1 June 2021 was conducted. The search terms included \"proton pump inhibitors,\" \"cancer,\" \"chemotherapy,\" \"immunotherapy,\" \"hormonotherapies,\" \"targeted therapies,\" \"tyrosine kinase inhibitors,\" and \"gut microbiome\"","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-05-31T13:00:59.826Z","creation":"2025-04-06T21:52:46.96Z"},"accession":"S-EPMC8963837","cross_references":{"pubmed":["35359844"],"doi":["10.3389/fphar.2022.798272"]}}