biostudies-literatureUnknown13Bridoux M<b>Background:</b> Proton pump inhibitors (PPIs) are one of the most widely used drugs worldwide and are overprescribed in patients with cancer; there is increasing evidence of their effects on cancer development and survival. The objective of this narrative review is to comprehensively identify cancer medications that have clinically meaningful drug-drug interactions (DDIs) with PPIs, including loss of efficacy or adverse effects, and to explore the association between PPIs and cancer. <b>Methods:</b> A PubMed search of English language studies published from 1 January 2016, to 1 June 2021 was conducted. The search terms included "proton pump inhibitors," "cancer," "chemotherapy," "immunotherapy," "hormonotherapies," "targeted therapies," "tyrosine kinase inhibitors," and "gut microbiome"Frontiers in pharmacology798272https://www.ebi.ac.uk/biostudies/studies/S-EPMC8963837biostudies-literatureProton Pump Inhibitors and Cancer: Current State of Play.PMC8963837Simon NBridoux MTurpin AfalseProton Pump Inhibitors and Cancer: Current State of Play.<b>Background:</b> Proton pump inhibitors (PPIs) are one of the most widely used drugs worldwide and are overprescribed in patients with cancer; there is increasing evidence of their effects on cancer development and survival. The objective of this narrative review is to comprehensively identify cancer medications that have clinically meaningful drug-drug interactions (DDIs) with PPIs, including loss of efficacy or adverse effects, and to explore the association between PPIs and cancer. <b>Methods:</b> A PubMed search of English language studies published from 1 January 2016, to 1 June 2021 was conducted. The search terms included "proton pump inhibitors," "cancer," "chemotherapy," "immunotherapy," "hormonotherapies," "targeted therapies," "tyrosine kinase inhibitors," and "gut microbiome"2022-01-01T00:00:00Z20222026-05-31T13:00:59.826Z2025-04-06T21:52:46.96ZS-EPMC89638373535984410.3389/fphar.2022.798272