biostudies-literatureSandler RSNIDDK NIH HHSe00467https://www.ebi.ac.uk/biostudies/studies/S-EPMC8963857biostudies-literatureUnknown13(3)<h4>Introduction</h4>Microscopic colitis, a common cause of diarrhea, is characterized by a largely normal appearance of the mucosa but increased numbers of lymphocytes in the epithelium and lamina propria on microscopy. We sought to determine whether T-cell percentage was associated with exposures or symptoms.<h4>Methods</h4>We conducted a case-control study that enrolled patients referred for colonoscopy for diarrhea. Patients were classified as microscopic colitis cases or controls by an experienced pathologist. Participants provided information on symptoms and exposures during a telephone or internet survey. Research biopsies from the ascending colon and descending colon were examined using immunofluorescence stains for CD3, CD8, and FOXP3 to determine percent T cells per total epithelClinical and translational gastroenterologyIntraepithelial and Lamina Propria Lymphocytes Do Not Correlate With Symptoms or Exposures in Microscopic Colitis.PMC8963857R01 DK105114P30 DK034987Sandler RSKeku TOHansen JJPeery AFWoosley JTGalanko JAfalseIntraepithelial and Lamina Propria Lymphocytes Do Not Correlate With Symptoms or Exposures in Microscopic Colitis.<h4>Introduction</h4>Microscopic colitis, a common cause of diarrhea, is characterized by a largely normal appearance of the mucosa but increased numbers of lymphocytes in the epithelium and lamina propria on microscopy. We sought to determine whether T-cell percentage was associated with exposures or symptoms.<h4>Methods</h4>We conducted a case-control study that enrolled patients referred for colonoscopy for diarrhea. Patients were classified as microscopic colitis cases or controls by an experienced pathologist. Participants provided information on symptoms and exposures during a telephone or internet survey. Research biopsies from the ascending colon and descending colon were examined using immunofluorescence stains for CD3, CD8, and FOXP3 to determine percent T cells per total epithel2022-01-01T00:00:00Z2022 Jan2025-04-04T21:33:23.955Z2025-04-04T21:33:23.955ZS-EPMC89638573516671410.14309/ctg.0000000000000467