{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Fan Z"],"pubmed_abstract":["<h4>Background</h4>Otolin-1 is an inner ear-specific protein that is exclusively expressed in otoconia and vestibule and cochlea cells. Recent investigations reported that otolin-1 can cross the blood-labyrinthine barrier and that the levels in serum well-reflected otolith status. Serum otolin-1 levels in patients with benign paroxysmal positional vertigo (BPPV) are significantly elevated compared with healthy controls. We aimed to explore whether otolin-1 can also serve as a biomarker for predicting BPPV recurrence.<h4>Method</h4>Patients at our institution with new-onset of idiopathic BPPV between May, 2017 and May, 2018 were recruited and followed up for 2 years. All demographic data of the patients were collected, and serum levels of otolin-1 and other laboratory indicators were measur"],"journal":["Frontiers in neurology"],"pagination":["841677"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8963966"],"repository":["biostudies-literature"],"pubmed_title":["High Serum Levels of Otolin-1 in Patients With Benign Paroxysmal Positional Vertigo Predict Recurrence."],"pmcid":["PMC8963966"],"pubmed_authors":["Liu X","Zhou M","Fan Z","Hu Z","Lu X","Han W","Yan W","Wu Y"],"additional_accession":[]},"is_claimable":false,"name":"High Serum Levels of Otolin-1 in Patients With Benign Paroxysmal Positional Vertigo Predict Recurrence.","description":"<h4>Background</h4>Otolin-1 is an inner ear-specific protein that is exclusively expressed in otoconia and vestibule and cochlea cells. Recent investigations reported that otolin-1 can cross the blood-labyrinthine barrier and that the levels in serum well-reflected otolith status. Serum otolin-1 levels in patients with benign paroxysmal positional vertigo (BPPV) are significantly elevated compared with healthy controls. We aimed to explore whether otolin-1 can also serve as a biomarker for predicting BPPV recurrence.<h4>Method</h4>Patients at our institution with new-onset of idiopathic BPPV between May, 2017 and May, 2018 were recruited and followed up for 2 years. All demographic data of the patients were collected, and serum levels of otolin-1 and other laboratory indicators were measur","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-22T07:48:28.891Z","creation":"2025-04-05T22:19:03.84Z"},"accession":"S-EPMC8963966","cross_references":{"pubmed":["35359660"],"doi":["10.3389/fneur.2022.841677"]}}