biostudies-literatureSchmidt-Andersen PBørnecancerfondenRigshospitaletDansk Kræftforsknings FondFabrikant Einar Willumsens MindelegatHelsefondenRegion HovedstadenDanske Fysioterapeuter833850https://www.ebi.ac.uk/biostudies/studies/S-EPMC8964065biostudies-literatureUnknown10<h4>Background</h4>Improved survival rates for children and adolescents diagnosed with cancer call for novel strategies for reducing short- and long-term treatment-related side effects. These include the physical and metabolic sequelae that are exacerbated by sedentary behavior and treatment-induced toxicities. We aim to investigate the effect of an integrative neuromuscular training intervention during the first 6 months of anti-cancer treatment primarily on muscle strength, and secondarily on exercise capacity, physical function, markers of metabolic syndrome, dysmetabolism, and health-related quality of life during and after ended treatment.<h4>Methods</h4>One hundred and twenty-seven children and adolescents, newly diagnosed with malignant and benign neoplasia, aged 6-17 years, and treFrontiers in pediatricsIntegrative Neuromuscular Training in Adolescents and Children Treated for Cancer (INTERACT): Study Protocol for a Multicenter, Two-Arm Parallel-Group Randomized Controlled Superiority Trial.PMC89640652019-5954Anna PouplierChristensen JFaigenbaum ADLarsen HBSchmiegelow KHasle HZhang HSchmidt-Andersen PHjalgrim LLMuller KGFridh MKLykkedegn SfalseIntegrative Neuromuscular Training in Adolescents and Children Treated for Cancer (INTERACT): Study Protocol for a Multicenter, Two-Arm Parallel-Group Randomized Controlled Superiority Trial.<h4>Background</h4>Improved survival rates for children and adolescents diagnosed with cancer call for novel strategies for reducing short- and long-term treatment-related side effects. These include the physical and metabolic sequelae that are exacerbated by sedentary behavior and treatment-induced toxicities. We aim to investigate the effect of an integrative neuromuscular training intervention during the first 6 months of anti-cancer treatment primarily on muscle strength, and secondarily on exercise capacity, physical function, markers of metabolic syndrome, dysmetabolism, and health-related quality of life during and after ended treatment.<h4>Methods</h4>One hundred and twenty-seven children and adolescents, newly diagnosed with malignant and benign neoplasia, aged 6-17 years, and tre2022-01-01T00:00:00Z20222026-04-08T18:02:33.356Z2024-11-19T21:17:50.349ZS-EPMC89640653535990910.3389/fped.2022.833850