biostudies-literatureUnknown19(3)Gao L<h4>Background</h4>The role of HOXA family genes in the occurrence and progression of a variety of human cancers has been scatteredly reported. However, there is no systematic study on the differential expression, prognostic significance and potential molecular mechanism of HOXA4 and HOXA5 in LUAD.<h4>Methods</h4>In-house immunohistochemistry (IHC), multi-center microarrays, RT-qPCR and RNA-seq data were incorporated for comprehensively evaluating the expression and prognostic value of HOXA4 and HOXA5 in LUAD. The mechanism of HOXA4 and HOXA5 in the formation and development of LUAD was analyzed from multiple aspects of immune correlations, upstream transcriptional regulation, functional states of single cells and co-expressed gene network. The functional roles of HOXA4 and HOXA5 in LUAD wInternational journal of medical sciences572-587https://www.ebi.ac.uk/biostudies/studies/S-EPMC8964330biostudies-literatureExpression Landscape and Functional Roles of HOXA4 and HOXA5 in Lung Adenocarcinoma.PMC8964330Dang YWYang DPHe RQChen GHou JYLi GSZhou HFHuang ZGGao LFeng ZBZeng JHLuo JYKong JLfalseExpression Landscape and Functional Roles of HOXA4 and HOXA5 in Lung Adenocarcinoma.<h4>Background</h4>The role of HOXA family genes in the occurrence and progression of a variety of human cancers has been scatteredly reported. However, there is no systematic study on the differential expression, prognostic significance and potential molecular mechanism of HOXA4 and HOXA5 in LUAD.<h4>Methods</h4>In-house immunohistochemistry (IHC), multi-center microarrays, RT-qPCR and RNA-seq data were incorporated for comprehensively evaluating the expression and prognostic value of HOXA4 and HOXA5 in LUAD. The mechanism of HOXA4 and HOXA5 in the formation and development of LUAD was analyzed from multiple aspects of immune correlations, upstream transcriptional regulation, functional states of single cells and co-expressed gene network. The functional roles of HOXA4 and HOXA5 in LUAD w2022-01-01T00:00:00Z20222025-06-01T02:35:26.646Z2025-06-01T02:35:26.646ZS-EPMC89643303537046310.7150/ijms.70445