{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Eymael J"],"funding":["Dutch Research Council (NWO)"],"pagination":["765887"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8964404"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10"],"pubmed_abstract":["It is well established that mammalian kidney epithelial cells contain a single non-motile primary cilium (9 + 0 pattern). However, we noted the presence of multiple motile cilia with a central microtubular pair (9 + 2 pattern) in kidney biopsies of 11 patients with various kidney diseases, using transmission electron microscopy. Immunofluorescence staining revealed the expression of the motile cilia-specific markers Radial Spoke Head Protein 4 homolog A, Forkhead-box-protein J1 and Regulatory factor X3. Multiciliated cells were exclusively observed in proximal tubuli and a relative frequent observation in human kidney tissue: in 16.7% of biopsies with tubular injury and atrophy (3 of 18 tissues), in 17.6% of biopsies from patients with membranous nephropathy (3 of 17 tissues) and in 10% of"],"journal":["Frontiers in cell and developmental biology"],"pubmed_title":["Motile Cilia on Kidney Proximal Tubular Epithelial Cells Are Associated With Tubular Injury and Interstitial Fibrosis."],"pmcid":["PMC8964404"],"funding_grant_id":["091.501.618","016.156.363"],"pubmed_authors":["Eymael J","Wetzels JF","Steenbergen E","Van der Vlag J","Jansen J","Mooren F","Willemsen B","Smeets B","Dijkman H","Xu J"],"additional_accession":[]},"is_claimable":false,"name":"Motile Cilia on Kidney Proximal Tubular Epithelial Cells Are Associated With Tubular Injury and Interstitial Fibrosis.","description":"It is well established that mammalian kidney epithelial cells contain a single non-motile primary cilium (9 + 0 pattern). However, we noted the presence of multiple motile cilia with a central microtubular pair (9 + 2 pattern) in kidney biopsies of 11 patients with various kidney diseases, using transmission electron microscopy. Immunofluorescence staining revealed the expression of the motile cilia-specific markers Radial Spoke Head Protein 4 homolog A, Forkhead-box-protein J1 and Regulatory factor X3. Multiciliated cells were exclusively observed in proximal tubuli and a relative frequent observation in human kidney tissue: in 16.7% of biopsies with tubular injury and atrophy (3 of 18 tissues), in 17.6% of biopsies from patients with membranous nephropathy (3 of 17 tissues) and in 10% of","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-05-18T12:07:35.109Z","creation":"2025-05-18T12:07:35.109Z"},"accession":"S-EPMC8964404","cross_references":{"pubmed":["35372336"],"doi":["10.3389/fcell.2022.765887"]}}