biostudies-literatureHergenroeder GWNCATS NIH HHSJSPS KAKENHI Grant-in-Aid for Scientific ResearchZOLL Circulation, Inc.NIH/NCATSThe Vivian L. Smith Foundation for Neurologic Research560-572https://www.ebi.ac.uk/biostudies/studies/S-EPMC8964656biostudies-literatureUnknown36(2)<h4>Background</h4>Hypothermia is neuroprotective in some ischemia-reperfusion injuries. Ischemia-reperfusion injury may occur with traumatic subdural hematoma (SDH). This study aimed to determine whether early induction and maintenance of hypothermia in patients with acute SDH would lead to decreased ischemia-reperfusion injury and improve global neurologic outcome.<h4>Methods</h4>This international, multicenter randomized controlled trial enrolled adult patients with SDH requiring evacuation of hematoma within 6 h of injury. The intervention was controlled temperature management of hypothermia to 35 °C prior to dura opening followed by 33 °C for 48 h compared with normothermia (37 °C). Investigators randomly assigned patients at a 1:1 ratio between hypothermia and normothermia. Blinded eNeurocritical careHypothermia for Patients Requiring Evacuation of Subdural Hematoma: A Multicenter Randomized Clinical Trial.PMC8964656UL1 TR000445, UL1 TR001105 and UL1 TR000371UL1 TR000371JP26293386UL1 TR001105UL1 TR000445Schmitt LHMcGlothlin AOkonkwo DOTimmons SDWilde EABerry DAViele KAhmad FMcCauley SRDiringer MNJagid JDash PKChoi HAKim DHYokobori SSuehiro EHergenroeder GWKitagawa RSDetry MATemkin NRBullock RSchmitt KNakamura YKuroda YPuccio AMfalseHypothermia for Patients Requiring Evacuation of Subdural Hematoma: A Multicenter Randomized Clinical Trial.<h4>Background</h4>Hypothermia is neuroprotective in some ischemia-reperfusion injuries. Ischemia-reperfusion injury may occur with traumatic subdural hematoma (SDH). This study aimed to determine whether early induction and maintenance of hypothermia in patients with acute SDH would lead to decreased ischemia-reperfusion injury and improve global neurologic outcome.<h4>Methods</h4>This international, multicenter randomized controlled trial enrolled adult patients with SDH requiring evacuation of hematoma within 6 h of injury. The intervention was controlled temperature management of hypothermia to 35 °C prior to dura opening followed by 33 °C for 48 h compared with normothermia (37 °C). Investigators randomly assigned patients at a 1:1 ratio between hypothermia and normothermia. Blinded e2022-01-01T00:00:00Z2022 Apr2026-05-31T06:02:08.993Z2025-02-19T01:55:10.821ZS-EPMC89646563451896810.1007/s12028-021-01334-w