biostudies-literatureUnknown12(1)Kim JIt is unclear which factors are associated with progressive sinus node dysfunction after cavotricuspid isthmus (CTI)-dependent atrial flutter (AFL) ablation. We sought to evaluate the incidence and predictors for permanent pacemaker (PPM) implantation after CTI-dependent AFL ablation. Between January 2011 and June 2021, 353 patients underwent CTI-dependent AFL ablation were studied. During a median follow-up of 31.6 months, 30 patients (8.5%) received PPM implantation, 24 for sick sinus syndrome and 6 for atrioventricular block. In multivariable model, prior atrial fibrillation (AF) (HR 3.570; 95% CI 1.034-12.325; P = 0.044), lowest previous sinus heart rate (HR 0.942; 95% CI 0.898-0.988; P = 0.015), and left atrial volume index (LAVI) (HR 1.067; 95% CI 1.024-1.112; P = 0.002) were indepenScientific reports5336https://www.ebi.ac.uk/biostudies/studies/S-EPMC8964688biostudies-literaturePredictors of permanent pacemaker implantation after sinus conversion of cavotricuspid isthmus-dependent atrial flutter.PMC8964688Chung TWKim JYLee SHOn YKPark KMChoi JHKim JPark SJKim HRKim JSfalsePredictors of permanent pacemaker implantation after sinus conversion of cavotricuspid isthmus-dependent atrial flutter.It is unclear which factors are associated with progressive sinus node dysfunction after cavotricuspid isthmus (CTI)-dependent atrial flutter (AFL) ablation. We sought to evaluate the incidence and predictors for permanent pacemaker (PPM) implantation after CTI-dependent AFL ablation. Between January 2011 and June 2021, 353 patients underwent CTI-dependent AFL ablation were studied. During a median follow-up of 31.6 months, 30 patients (8.5%) received PPM implantation, 24 for sick sinus syndrome and 6 for atrioventricular block. In multivariable model, prior atrial fibrillation (AF) (HR 3.570; 95% CI 1.034-12.325; P = 0.044), lowest previous sinus heart rate (HR 0.942; 95% CI 0.898-0.988; P = 0.015), and left atrial volume index (LAVI) (HR 1.067; 95% CI 1.024-1.112; P = 0.002) were indepen2022-01-01T00:00:00Z2022 Mar2025-04-19T20:11:54.508Z2025-04-19T20:11:54.508ZS-EPMC89646883535198110.1038/s41598-022-09439-8