{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13(1)"],"submitter":["Zhang P"],"pubmed_abstract":["Oleaginous microalgae can produce triacylglycerol (TAG) under stress, yet the underlying mechanism remains largely unknown. Here, we show that, in Nannochloropsis oceanica, a bZIP-family regulator NobZIP77 represses the transcription of a type-2 diacylgycerol acyltransferase encoding gene NoDGAT2B under nitrogen-repletion (N+), while nitrogen-depletion (N-) relieves such inhibition and activates NoDGAT2B expression and synthesis of TAG preferably from C16:1. Intriguingly, NobZIP77 is a sensor of blue light (BL), which reduces binding of NobZIP77 to the NoDGAT2B-promoter, unleashes NoDGAT2B and elevates TAG under N-. Under N+ and white light, NobZIP77 knockout fully preserves cell growth rate and nearly triples TAG productivity. Moreover, exposing the NobZIP77-knockout line to BL under N- c"],"journal":["Nature communications"],"pagination":["1664"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8964759"],"repository":["biostudies-literature"],"pubmed_title":["Exploring a blue-light-sensing transcription factor to double the peak productivity of oil in Nannochloropsis oceanica."],"pmcid":["PMC8964759"],"pubmed_authors":["Li Y","He Y","Wang Q","Shen C","Lv N","Hu Q","Xu J","Zhang P","Xin Y","Tang X"],"additional_accession":[]},"is_claimable":false,"name":"Exploring a blue-light-sensing transcription factor to double the peak productivity of oil in Nannochloropsis oceanica.","description":"Oleaginous microalgae can produce triacylglycerol (TAG) under stress, yet the underlying mechanism remains largely unknown. Here, we show that, in Nannochloropsis oceanica, a bZIP-family regulator NobZIP77 represses the transcription of a type-2 diacylgycerol acyltransferase encoding gene NoDGAT2B under nitrogen-repletion (N+), while nitrogen-depletion (N-) relieves such inhibition and activates NoDGAT2B expression and synthesis of TAG preferably from C16:1. Intriguingly, NobZIP77 is a sensor of blue light (BL), which reduces binding of NobZIP77 to the NoDGAT2B-promoter, unleashes NoDGAT2B and elevates TAG under N-. Under N+ and white light, NobZIP77 knockout fully preserves cell growth rate and nearly triples TAG productivity. Moreover, exposing the NobZIP77-knockout line to BL under N- c","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2026-05-09T15:08:48.665Z","creation":"2024-11-14T23:50:48.977Z"},"accession":"S-EPMC8964759","cross_references":{"pubmed":["35351909"],"doi":["10.1038/s41467-022-29337-x"]}}