{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Barbier A"],"funding":["Canadian Institutes of Health Research"],"pubmed_abstract":["The quest to understand the pathophysiology of autism spectrum disorder (ASD) has led to extensive literature that purports to provide evidence for autonomic dysfunction based on heart rate and heart rate variability (HRV), in particular respiratory sinus arrhythmia (RSA), a measure of parasympathetic functioning. Many studies conclude that autism is associated with vagal withdrawal and sympathetic hyperactivation based on HRV and electrodermal analyses. We will argue that a critical analysis of the data leads to the hypothesis that autonomic nervous system dysfunction is not a dominant feature of autism. Most children with ASD have normal parasympathetic baseline values and normal autonomic responses to social stimuli. The existing HRV and electrodermal data cannot lead to the conclusion "],"journal":["Frontiers in psychiatry"],"pagination":["830234"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8964964"],"repository":["biostudies-literature"],"pubmed_title":["Autism Spectrum Disorder in Children Is Not Associated With Abnormal Autonomic Nervous System Function: Hypothesis and Theory."],"pmcid":["PMC8964964"],"pubmed_authors":["Huizinga JD","Barbier A","Chen JH"],"additional_accession":[]},"is_claimable":false,"name":"Autism Spectrum Disorder in Children Is Not Associated With Abnormal Autonomic Nervous System Function: Hypothesis and Theory.","description":"The quest to understand the pathophysiology of autism spectrum disorder (ASD) has led to extensive literature that purports to provide evidence for autonomic dysfunction based on heart rate and heart rate variability (HRV), in particular respiratory sinus arrhythmia (RSA), a measure of parasympathetic functioning. Many studies conclude that autism is associated with vagal withdrawal and sympathetic hyperactivation based on HRV and electrodermal analyses. We will argue that a critical analysis of the data leads to the hypothesis that autonomic nervous system dysfunction is not a dominant feature of autism. Most children with ASD have normal parasympathetic baseline values and normal autonomic responses to social stimuli. The existing HRV and electrodermal data cannot lead to the conclusion ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-05T22:20:27.426Z","creation":"2025-04-05T22:20:27.426Z"},"accession":"S-EPMC8964964","cross_references":{"pubmed":["35370829"],"doi":["10.3389/fpsyt.2022.830234"]}}