{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ma L"],"funding":["Bureau of Science and Technology of Zhoushan","Fundamental Research Funds for the Central Universities","National Natural Science Foundation of China","National Key Research and Development Program of China"],"pagination":["425-438"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8964989"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17"],"pubmed_abstract":["Nanotopographical cues endow biomaterials the ability to guide cell adhesion, proliferation, and differentiation. Cellular mechanical memory can maintain the cell status by retaining cellular information obtained from past mechanical microenvironments. Here, we propose a new concept \"morphology memory of small extracellular vesicles (sEV)\" for bone regeneration. We performed nanotopography on titanium plates through alkali and heat (Ti8) treatment to promote human mesenchymal stem cell (hMSC) differentiation. Next, we extracted the sEVs from the hMSC, which were cultured on the nanotopographical Ti plates for 21 days (Ti8-21-sEV). We demonstrated that Ti8-21-sEV had superior pro-osteogenesis ability <i>in vitro</i> and <i>in vivo</i>. RNA sequencing further confirmed that Ti8-21-sEV promot"],"journal":["Bioactive materials"],"pubmed_title":["Small extracellular vesicles with nanomorphology memory promote osteogenesis."],"pmcid":["PMC8964989"],"funding_grant_id":["2019kfyXMBZ063","2018YFB1105700","81772401","2019020701011457","81902261"],"pubmed_authors":["Liao Z","Li G","Sheng W","Ma L","Lei J","Wang B","Feng X","Yang C","Wang K","Shi Y","Zhang W","Ke W","Luo R","Song Y"],"additional_accession":[]},"is_claimable":false,"name":"Small extracellular vesicles with nanomorphology memory promote osteogenesis.","description":"Nanotopographical cues endow biomaterials the ability to guide cell adhesion, proliferation, and differentiation. Cellular mechanical memory can maintain the cell status by retaining cellular information obtained from past mechanical microenvironments. Here, we propose a new concept \"morphology memory of small extracellular vesicles (sEV)\" for bone regeneration. We performed nanotopography on titanium plates through alkali and heat (Ti8) treatment to promote human mesenchymal stem cell (hMSC) differentiation. Next, we extracted the sEVs from the hMSC, which were cultured on the nanotopographical Ti plates for 21 days (Ti8-21-sEV). We demonstrated that Ti8-21-sEV had superior pro-osteogenesis ability <i>in vitro</i> and <i>in vivo</i>. RNA sequencing further confirmed that Ti8-21-sEV promot","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2025-04-19T20:09:27.694Z","creation":"2025-04-19T20:09:27.694Z"},"accession":"S-EPMC8964989","cross_references":{"pubmed":["35386457"],"doi":["10.1016/j.bioactmat.2022.01.008"]}}