biostudies-literatureUnknown9(2)Yaghi NK<h4>Background</h4>There is growing evidence supporting the need for a short time delay before starting radiotherapy (RT) treatment postsurgery for most optimal responses. The timing of RT initiation and effects on outcomes have been evaluated in a variety of malignancies, but the relationship remains to be well established for brain metastasis.<h4>Methods</h4>Retrospective study of 176 patients (aged 18-89 years) with brain metastases at a single institution (March 2009 to August 2018) who received RT following surgical resection. Time interval (≤22 and >22 days) from surgical resection to initiation of RT and any potential impact on patient outcomes were assessed.<h4>Results</h4>Patients who underwent RT >22 days after surgical resection had a decreased risk for all-cause mortality of 47Neuro-oncology practice133-141https://www.ebi.ac.uk/biostudies/studies/S-EPMC8965066biostudies-literatureOptimal timing of radiotherapy following brain metastases surgery.PMC8965066Radu SBowden SGNugent JGHan SJMazur-Hart DJYaghi NKPang BWMurphy BfalseOptimal timing of radiotherapy following brain metastases surgery.<h4>Background</h4>There is growing evidence supporting the need for a short time delay before starting radiotherapy (RT) treatment postsurgery for most optimal responses. The timing of RT initiation and effects on outcomes have been evaluated in a variety of malignancies, but the relationship remains to be well established for brain metastasis.<h4>Methods</h4>Retrospective study of 176 patients (aged 18-89 years) with brain metastases at a single institution (March 2009 to August 2018) who received RT following surgical resection. Time interval (≤22 and >22 days) from surgical resection to initiation of RT and any potential impact on patient outcomes were assessed.<h4>Results</h4>Patients who underwent RT >22 days after surgical resection had a decreased risk for all-cause mortality of 472022-01-01T00:00:00Z2022 Apr2025-04-06T19:15:49.698Z2025-04-06T19:15:49.698ZS-EPMC89650663537152410.1093/nop/npac007