biostudies-literatureUnknown16Ea C<h4>Objective</h4>Faciocraniosynostoses (FCS) are malformations affecting the development of the bones of the skull and face, due to the premature closure of one or more craniofacial sutures, mostly secondary to activating <i>Fibroblast Growth Factor Receptor</i> (<i>FGFR</i>) 1-3 mutations. Gain-of-function <i>FGFR3</i> mutations are also responsible for various conditions referred to as osteochondrodysplasia (OCD), characterized by structural and functional abnormalities of growth plate cartilages. We hypothesized that patients with <i>FGFR</i>-related faciocraniosynostoses may present extra-cranial growth anomalies.<h4>Study design</h4>We retrospectively collected height and weight data from a cohort of 70 patients. Included patients were admitted for <i>FGFR</i>-related FCS between 200Bone reports101524https://www.ebi.ac.uk/biostudies/studies/S-EPMC8965158biostudies-literatureGrowth charts in <i>FGFR2</i>- and <i>FGFR3</i>-related faciocraniosynostoses.PMC8965158Collet CHennocq QPicard APolak MKhonsari RHLegeai-Mallet LPaternoster GArnaud EEa CfalseGrowth charts in <i>FGFR2</i>- and <i>FGFR3</i>-related faciocraniosynostoses.<h4>Objective</h4>Faciocraniosynostoses (FCS) are malformations affecting the development of the bones of the skull and face, due to the premature closure of one or more craniofacial sutures, mostly secondary to activating <i>Fibroblast Growth Factor Receptor</i> (<i>FGFR</i>) 1-3 mutations. Gain-of-function <i>FGFR3</i> mutations are also responsible for various conditions referred to as osteochondrodysplasia (OCD), characterized by structural and functional abnormalities of growth plate cartilages. We hypothesized that patients with <i>FGFR</i>-related faciocraniosynostoses may present extra-cranial growth anomalies.<h4>Study design</h4>We retrospectively collected height and weight data from a cohort of 70 patients. Included patients were admitted for <i>FGFR</i>-related FCS between 2002022-01-01T00:00:00Z2022 Jun2025-04-04T23:16:26.688Z2025-04-04T23:16:26.688ZS-EPMC89651583537264410.1016/j.bonr.2022.101524