{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["36(2)"],"submitter":["Gold JR"],"pubmed_abstract":["<h4>Background</h4>The repeated administration of high doses of gabapentin may provide better analgesia in horses than current clinical protocols.<h4>Hypothesis and objectives</h4>Administration of gabapentin at 40 and 120 mg/kg PO q 12 h for 14 days will not alter serum biochemistry findings or cause adverse effects. Our objectives were to evaluate the effect of gabapentin on serum biochemistry, physical examination, and plasma pharmacokinetics of gabapentin.<h4>Animals</h4>Six healthy adult mares.<h4>Methods</h4>Horses received 40 and 120 mg/kg of gabapentin orally q 12 h for 14 days. Horses were examined and scored for ataxia and sedation daily. Serum biochemistry variables were analyzed before treatment and days 7 and 14 after gabapentin administration. Plasma disposition of gabapentin"],"journal":["Journal of veterinary internal medicine"],"pagination":["792-797"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8965223"],"repository":["biostudies-literature"],"pubmed_title":["Pharmacokinetics and pharmacodynamics of repeat dosing of gabapentin in adult horses."],"pmcid":["PMC8965223"],"pubmed_authors":["Villarino NL","Cox S","Gold JR","Grubb TL","Malavasi L"],"additional_accession":[]},"is_claimable":false,"name":"Pharmacokinetics and pharmacodynamics of repeat dosing of gabapentin in adult horses.","description":"<h4>Background</h4>The repeated administration of high doses of gabapentin may provide better analgesia in horses than current clinical protocols.<h4>Hypothesis and objectives</h4>Administration of gabapentin at 40 and 120 mg/kg PO q 12 h for 14 days will not alter serum biochemistry findings or cause adverse effects. Our objectives were to evaluate the effect of gabapentin on serum biochemistry, physical examination, and plasma pharmacokinetics of gabapentin.<h4>Animals</h4>Six healthy adult mares.<h4>Methods</h4>Horses received 40 and 120 mg/kg of gabapentin orally q 12 h for 14 days. Horses were examined and scored for ataxia and sedation daily. Serum biochemistry variables were analyzed before treatment and days 7 and 14 after gabapentin administration. Plasma disposition of gabapentin","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2026-06-18T05:44:11.52Z","creation":"2025-04-06T14:51:56.803Z"},"accession":"S-EPMC8965223","cross_references":{"pubmed":["35150014"],"doi":["10.1111/jvim.16386"]}}