{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["36(2)"],"submitter":["Durand A"],"pubmed_abstract":["<h4>Background</h4>Lymphoma is the most common spinal cord neoplasm and second most common intracranial tumor in cats, but description of specific magnetic resonance imaging (MRI) features is lacking.<h4>Objective</h4>Describe the clinical and MRI features of lymphoma affecting the central (CNS) or peripheral (PNS) nervous system or both in cats.<h4>Animals</h4>Thirty-one cats with confirmed cytological or histopathological diagnosis or both of lymphoma involving the CNS or PNS or both, and MRI findings of the lesions.<h4>Methods</h4>Multicenter retrospective descriptive study. Signalment and medical information were recorded. Magnetic resonance imaging findings were reviewed by 3 observers following a list of predefined criteria and consensus was sought. Frequency distributions of the different categorical data were reported.<h4>Results</h4>Median duration of clinical signs at time of presentation was 14 days (range, 1-90). Neurological examination was abnormal in 30/31 cats. On MRI, lesions affecting the CNS were diagnosed in 18/31 cats, lesions in both CNS and PNS in 12/31, and lesions in the PNS only in 1/31. Intracranial lesions were diagnosed in 22 cats (extra-axial, 7/22; intra-axial, 2/22; mixed, 13/22), and spinal lesions were diagnosed in 12 (6/12 involving the conus medullaris and lumbosacral plexuses). Infiltration of adjacent extra-neural tissue was present in 11/31 cases. Contrast enhancement was seen in all lesions, being marked in 25/30. Meningeal enhancement was present in all but 2 cases. Several distinct MRI patterns were observed.<h4>Conclusions and clinical importance</h4>Nervous system lymphoma in cats has a wide range of MRI features, of which none is pathognomonic. However, together with clinical data and cerebrospinal fluid (CSF) analysis, MRI may provide a strong tentative antemortem diagnosis."],"journal":["Journal of veterinary internal medicine"],"pagination":["679-693"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8965233"],"repository":["biostudies-literature"],"pubmed_title":["Clinical and magnetic resonance imaging features of lymphoma involving the nervous system in cats."],"pmcid":["PMC8965233"],"pubmed_authors":["Gutierrez-Quintana R","Schweizer D","Keenihan E","Guevar J","Maiolini A","Durand A","Oevermann A"],"additional_accession":[]},"is_claimable":false,"name":"Clinical and magnetic resonance imaging features of lymphoma involving the nervous system in cats.","description":"<h4>Background</h4>Lymphoma is the most common spinal cord neoplasm and second most common intracranial tumor in cats, but description of specific magnetic resonance imaging (MRI) features is lacking.<h4>Objective</h4>Describe the clinical and MRI features of lymphoma affecting the central (CNS) or peripheral (PNS) nervous system or both in cats.<h4>Animals</h4>Thirty-one cats with confirmed cytological or histopathological diagnosis or both of lymphoma involving the CNS or PNS or both, and MRI findings of the lesions.<h4>Methods</h4>Multicenter retrospective descriptive study. Signalment and medical information were recorded. Magnetic resonance imaging findings were reviewed by 3 observers following a list of predefined criteria and consensus was sought. Frequency distributions of the different categorical data were reported.<h4>Results</h4>Median duration of clinical signs at time of presentation was 14 days (range, 1-90). Neurological examination was abnormal in 30/31 cats. On MRI, lesions affecting the CNS were diagnosed in 18/31 cats, lesions in both CNS and PNS in 12/31, and lesions in the PNS only in 1/31. Intracranial lesions were diagnosed in 22 cats (extra-axial, 7/22; intra-axial, 2/22; mixed, 13/22), and spinal lesions were diagnosed in 12 (6/12 involving the conus medullaris and lumbosacral plexuses). Infiltration of adjacent extra-neural tissue was present in 11/31 cases. Contrast enhancement was seen in all lesions, being marked in 25/30. Meningeal enhancement was present in all but 2 cases. Several distinct MRI patterns were observed.<h4>Conclusions and clinical importance</h4>Nervous system lymphoma in cats has a wide range of MRI features, of which none is pathognomonic. However, together with clinical data and cerebrospinal fluid (CSF) analysis, MRI may provide a strong tentative antemortem diagnosis.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2026-06-19T04:50:15.988Z","creation":"2026-06-19T03:07:28.375Z"},"accession":"S-EPMC8965233","cross_references":{"pubmed":["35048412"],"doi":["10.1111/jvim.16350"]}}