{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Goncalves da Costa Sousa M"],"funding":["Fundação de Apoio ao Desenvolvimento do Ensino, Ciência e Tecnologia do Estado de Mato Grosso do Sul","Universidade de Brasília","Fundação de Apoio à Pesquisa do Distrito Federal","Conselho Nacional de Desenvolvimento Científico e Tecnológico","Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","Michael Smith Foundation for Health Research","University of British Columbia","Canadian Institutes of Health Research"],"pagination":["173-186"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8965695"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16"],"pubmed_abstract":["Multifunctional scaffolds with host defense peptides designed for regenerative endodontics are desirable nanobiotechnological tools for dentistry. Here, different scaffolds were tested for use during the pulp revascularization process, including poly(vinyl alcohol)-PVA hydrogels or resins, collagen hydrogels and poly(vinyl alcohol) PVA/Chitosan (PVA/CS) nanofibers. Based on time to degradation (21 days), nanofibers were chosen to be incorporated with ciprofloxacin and IDR-1002 (each at 50 mg/g). Nanofibers containing ciprofloxacin and IDR-1002 had anti-biofilm activity against <i>Enterococcus faecalis, Staphylococcus aureus</i> and a multispecies oral biofilm, besides anti-inflammatory activities. The <i>in vivo</i> subcutaneous tissue response to tooth fragments filled with nanofibers dem"],"journal":["Bioactive materials"],"pubmed_title":["Antibiofilm and immunomodulatory resorbable nanofibrous filing for dental pulp regenerative procedures."],"pmcid":["PMC8965695"],"funding_grant_id":["88887.202222/2018–00","FDN-154287","409196/2018–5","59/300.397/2015","00193–00000782/2021-63"],"pubmed_authors":["Limberger SN","Berto Rezende TM","Goncalves da Costa Sousa M","Ko F","Conceicao de Almeida G","Andrade da Costa R","Etayash H","Franco OL","Haapasalo M","Pletzer D","Martins Mota DC","Baquir B","Schuindt Teixeira G","Haney EF","Trimble MJ","Hancock REW","Dias SC","Su Z","Shen Y","Silva RM","Lin LT","Chaves de Souza L"],"additional_accession":[]},"is_claimable":false,"name":"Antibiofilm and immunomodulatory resorbable nanofibrous filing for dental pulp regenerative procedures.","description":"Multifunctional scaffolds with host defense peptides designed for regenerative endodontics are desirable nanobiotechnological tools for dentistry. Here, different scaffolds were tested for use during the pulp revascularization process, including poly(vinyl alcohol)-PVA hydrogels or resins, collagen hydrogels and poly(vinyl alcohol) PVA/Chitosan (PVA/CS) nanofibers. Based on time to degradation (21 days), nanofibers were chosen to be incorporated with ciprofloxacin and IDR-1002 (each at 50 mg/g). Nanofibers containing ciprofloxacin and IDR-1002 had anti-biofilm activity against <i>Enterococcus faecalis, Staphylococcus aureus</i> and a multispecies oral biofilm, besides anti-inflammatory activities. The <i>in vivo</i> subcutaneous tissue response to tooth fragments filled with nanofibers dem","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2025-04-04T12:57:54.691Z","creation":"2025-04-04T12:57:54.691Z"},"accession":"S-EPMC8965695","cross_references":{"pubmed":["35386316"],"doi":["10.1016/j.bioactmat.2022.01.027"]}}