{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12"],"submitter":["Lai HY"],"pubmed_abstract":["<h4>Background</h4>Urothelial carcinoma (UC) patients often bear clinical and genetic heterogeneity, which may differ in management and prognosis. Especially, patients with advanced/metastatic UC generally have a poor prognosis and survive for only few months. The Wnt/β-catenin signaling is found to be highly activated in several cancers, including UC. However, accumulated evidence has shown discordance between the Wnt/β-catenin signaling and UC carcinogenesis. Accordingly, we aim to get a better understanding of the molecular characterization of UC, focusing on the Wnt signaling, which may add value to guiding management more precisely.<h4>Patients and methods</h4>Clinical data and pathological features were retrospectively surveyed. The correlations of secreted Frizzled-related protein 2"],"journal":["Frontiers in oncology"],"pagination":["834249"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8965759"],"repository":["biostudies-literature"],"pubmed_title":["High Stromal SFRP2 Expression in Urothelial Carcinoma Confers an Unfavorable Prognosis."],"pmcid":["PMC8965759"],"pubmed_authors":["Tseng WH","Kuo YH","Hsing CH","Tsai HH","Wu LC","Chiu CC","Li CF","Lai HY","Huang SK","Liu CL"],"additional_accession":[]},"is_claimable":false,"name":"High Stromal SFRP2 Expression in Urothelial Carcinoma Confers an Unfavorable Prognosis.","description":"<h4>Background</h4>Urothelial carcinoma (UC) patients often bear clinical and genetic heterogeneity, which may differ in management and prognosis. Especially, patients with advanced/metastatic UC generally have a poor prognosis and survive for only few months. The Wnt/β-catenin signaling is found to be highly activated in several cancers, including UC. However, accumulated evidence has shown discordance between the Wnt/β-catenin signaling and UC carcinogenesis. Accordingly, we aim to get a better understanding of the molecular characterization of UC, focusing on the Wnt signaling, which may add value to guiding management more precisely.<h4>Patients and methods</h4>Clinical data and pathological features were retrospectively surveyed. The correlations of secreted Frizzled-related protein 2","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-07-14T14:22:26.296Z","creation":"2026-06-19T03:07:31.717Z"},"accession":"S-EPMC8965759","cross_references":{"pubmed":["35372028"],"doi":["10.3389/fonc.2022.834249"]}}