biostudies-literatureUnknown12Lai HY<h4>Background</h4>Urothelial carcinoma (UC) patients often bear clinical and genetic heterogeneity, which may differ in management and prognosis. Especially, patients with advanced/metastatic UC generally have a poor prognosis and survive for only few months. The Wnt/β-catenin signaling is found to be highly activated in several cancers, including UC. However, accumulated evidence has shown discordance between the Wnt/β-catenin signaling and UC carcinogenesis. Accordingly, we aim to get a better understanding of the molecular characterization of UC, focusing on the Wnt signaling, which may add value to guiding management more precisely.<h4>Patients and methods</h4>Clinical data and pathological features were retrospectively surveyed. The correlations of secreted Frizzled-related protein 2Frontiers in oncology834249https://www.ebi.ac.uk/biostudies/studies/S-EPMC8965759biostudies-literatureHigh Stromal SFRP2 Expression in Urothelial Carcinoma Confers an Unfavorable Prognosis.PMC8965759Tseng WHKuo YHHsing CHTsai HHWu LCChiu CCLi CFLai HYHuang SKLiu CLfalseHigh Stromal SFRP2 Expression in Urothelial Carcinoma Confers an Unfavorable Prognosis.<h4>Background</h4>Urothelial carcinoma (UC) patients often bear clinical and genetic heterogeneity, which may differ in management and prognosis. Especially, patients with advanced/metastatic UC generally have a poor prognosis and survive for only few months. The Wnt/β-catenin signaling is found to be highly activated in several cancers, including UC. However, accumulated evidence has shown discordance between the Wnt/β-catenin signaling and UC carcinogenesis. Accordingly, we aim to get a better understanding of the molecular characterization of UC, focusing on the Wnt signaling, which may add value to guiding management more precisely.<h4>Patients and methods</h4>Clinical data and pathological features were retrospectively surveyed. The correlations of secreted Frizzled-related protein 22022-01-01T00:00:00Z20222026-07-14T14:22:26.296Z2026-06-19T03:07:31.717ZS-EPMC89657593537202810.3389/fonc.2022.834249