{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["22(1)"],"submitter":["Zarrabi M"],"funding":["Tehran University of Medical Sciences"],"pubmed_abstract":["<h4>Introduction</h4>The current multi-center, randomized, double-blind study was conducted among children with cerebral palsy (CP) to assess the safety and efficacy of umbilical cord blood mononuclear cell (UCB-MNC). We performed the diffusion tensor imaging to assess the changes in the white matter structure.<h4>Methods</h4>Males and females aged 4 to 14 years old with spastic CP were included. Eligible participants were allocated in 4:1 ratio to be in the experimental or control groups; respectively. Individuals who were assigned in UCB-MNC group were tested for human leukocyte antigen (HLA) and fully-matched individuals were treated with UCB-MNCs. A single dose (5 × 10<sup>6</sup> /kg) UCB-MNCs were administered via intrathecal route in experimental group. The changes in gross motor fu"],"journal":["BMC neurology"],"pagination":["123"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8966246"],"repository":["biostudies-literature"],"pubmed_title":["The safety and efficacy of umbilical cord blood mononuclear cells in individuals with spastic cerebral palsy: a randomized double-blind sham-controlled clinical trial."],"pmcid":["PMC8966246"],"pubmed_authors":["Shodjaee R","Karimi H","Mohebbi A","Badv RS","Valizadeh A","Ashrafi MR","Goudarzi M","Mohammad M","Rahimi R","Gholami M","Rahimi-Dehgolan S","Tavasoli AR","Mohammadi M","Zamani GR","Zarrabi M","Moaiedi AR","Abroun S","Koochakzadeh L","Samimi S","Taghdiri MM","Masoomi S","Alizadeh H","Javadzadeh M","Akbari MG","Hassanpour SH","Shamsabadi FM","Malamiri RA","Rabbani A","Mohseni MJ","Amanat M","Dehghan E","Nouri M","Vafaei N","Montazerlotfelahi H","Ghofrani M","Heidari M","Vosough M","Hamidieh AA","Mohamadpour M","Pak N","Majmaa A","Noparast Z"],"additional_accession":[]},"is_claimable":false,"name":"The safety and efficacy of umbilical cord blood mononuclear cells in individuals with spastic cerebral palsy: a randomized double-blind sham-controlled clinical trial.","description":"<h4>Introduction</h4>The current multi-center, randomized, double-blind study was conducted among children with cerebral palsy (CP) to assess the safety and efficacy of umbilical cord blood mononuclear cell (UCB-MNC). We performed the diffusion tensor imaging to assess the changes in the white matter structure.<h4>Methods</h4>Males and females aged 4 to 14 years old with spastic CP were included. Eligible participants were allocated in 4:1 ratio to be in the experimental or control groups; respectively. Individuals who were assigned in UCB-MNC group were tested for human leukocyte antigen (HLA) and fully-matched individuals were treated with UCB-MNCs. A single dose (5 × 10<sup>6</sup> /kg) UCB-MNCs were administered via intrathecal route in experimental group. The changes in gross motor fu","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2026-05-31T21:04:38.704Z","creation":"2025-04-04T19:30:33.574Z"},"accession":"S-EPMC8966246","cross_references":{"pubmed":["35351020"],"doi":["10.1186/s12883-022-02636-y"]}}