biostudies-literatureUnknown22(1)Zarrabi MTehran University of Medical Sciences<h4>Introduction</h4>The current multi-center, randomized, double-blind study was conducted among children with cerebral palsy (CP) to assess the safety and efficacy of umbilical cord blood mononuclear cell (UCB-MNC). We performed the diffusion tensor imaging to assess the changes in the white matter structure.<h4>Methods</h4>Males and females aged 4 to 14 years old with spastic CP were included. Eligible participants were allocated in 4:1 ratio to be in the experimental or control groups; respectively. Individuals who were assigned in UCB-MNC group were tested for human leukocyte antigen (HLA) and fully-matched individuals were treated with UCB-MNCs. A single dose (5 × 10⁶ /kg) UCB-MNCs were administered via intrathecal route in experimental group. The changes in gross motor fuBMC neurology123https://www.ebi.ac.uk/biostudies/studies/S-EPMC8966246biostudies-literatureThe safety and efficacy of umbilical cord blood mononuclear cells in individuals with spastic cerebral palsy: a randomized double-blind sham-controlled clinical trial.PMC8966246Shodjaee RKarimi HMohebbi ABadv RSValizadeh AAshrafi MRGoudarzi MMohammad MRahimi RGholami MRahimi-Dehgolan STavasoli ARMohammadi MZamani GRZarrabi MMoaiedi ARAbroun SKoochakzadeh LSamimi STaghdiri MMMasoomi SAlizadeh HJavadzadeh MAkbari MGHassanpour SHShamsabadi FMMalamiri RARabbani AMohseni MJAmanat MDehghan ENouri MVafaei NMontazerlotfelahi HGhofrani MHeidari MVosough MHamidieh AAMohamadpour MPak NMajmaa ANoparast ZfalseThe safety and efficacy of umbilical cord blood mononuclear cells in individuals with spastic cerebral palsy: a randomized double-blind sham-controlled clinical trial.<h4>Introduction</h4>The current multi-center, randomized, double-blind study was conducted among children with cerebral palsy (CP) to assess the safety and efficacy of umbilical cord blood mononuclear cell (UCB-MNC). We performed the diffusion tensor imaging to assess the changes in the white matter structure.<h4>Methods</h4>Males and females aged 4 to 14 years old with spastic CP were included. Eligible participants were allocated in 4:1 ratio to be in the experimental or control groups; respectively. Individuals who were assigned in UCB-MNC group were tested for human leukocyte antigen (HLA) and fully-matched individuals were treated with UCB-MNCs. A single dose (5 × 10⁶ /kg) UCB-MNCs were administered via intrathecal route in experimental group. The changes in gross motor fu2022-01-01T00:00:00Z2022 Mar2026-05-31T21:04:38.704Z2025-04-04T19:30:33.574ZS-EPMC89662463535102010.1186/s12883-022-02636-y