biostudies-literatureUnknown40(10)Di Meglio A<h4>Purpose</h4>Fatigue is common and troublesome among breast cancer survivors; however, limited tools exist to predict its risk.<h4>Patients and methods</h4>Participants with stage I-III breast cancer were prospectively included from CANTO (ClinicalTrials.gov identifier: NCT01993498), collecting longitudinal data at diagnosis (before the initiation of any cancer treatment) and 1 (T1), 2 (T2), and 4 (T3) years after diagnosis. The main outcome was severe global fatigue at T2 (score ≥ 40/100, European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire-C30). Analyses at T3 were exploratory. Secondary outcomes included physical, emotional, and cognitive fatigue (EORTC Quality of Life Questionnaire-FA12). Multivariable logistic regression models retained aJournal of clinical oncology : official journal of the American Society of Clinical Oncology1111-1123https://www.ebi.ac.uk/biostudies/studies/S-EPMC8966972biostudies-literatureDevelopment and Validation of a Predictive Model of Severe Fatigue After Breast Cancer Diagnosis: Toward a Personalized Framework in Survivorship Care.PMC8966972Presti DMichiels SLevy CSoldato DHavas JMartin ALEverhard SPistilli BGanz PACharles CRigal OVaz-Luis ITarpin CAndre FMenvielle GMartin EDumas AVanlemmens LPartridge AHDi Meglio ALin NUCoutant CDelaloge SfalseDevelopment and Validation of a Predictive Model of Severe Fatigue After Breast Cancer Diagnosis: Toward a Personalized Framework in Survivorship Care.<h4>Purpose</h4>Fatigue is common and troublesome among breast cancer survivors; however, limited tools exist to predict its risk.<h4>Patients and methods</h4>Participants with stage I-III breast cancer were prospectively included from CANTO (ClinicalTrials.gov identifier: NCT01993498), collecting longitudinal data at diagnosis (before the initiation of any cancer treatment) and 1 (T1), 2 (T2), and 4 (T3) years after diagnosis. The main outcome was severe global fatigue at T2 (score ≥ 40/100, European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire-C30). Analyses at T3 were exploratory. Secondary outcomes included physical, emotional, and cognitive fatigue (EORTC Quality of Life Questionnaire-FA12). Multivariable logistic regression models retained a2022-01-01T00:00:00Z2022 Apr2025-04-26T13:17:50.431Z2024-11-20T21:02:26.902ZS-EPMC89669723506150910.1200/JCO.21.01252