{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Triantafyllou P"],"funding":["Wellcome Trust"],"pagination":["e0265421"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8967029"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(3)"],"pubmed_abstract":["<h4>Objective</h4>Depression often co-occurs with poor health-related quality of life (HRQL). Twin studies report genetic and individual-level environmental underpinnings in the aetiology of both depression and HRQL, but there is limited twin research exploring this association further. There is also little evidence on sex differences and non-Western populations are underrepresented. In this paper we explored the phenotypic and aetiological relationship between depressive symptoms and HRQL and possible sex differences in a low-middle-income Sri Lankan population.<h4>Method</h4>Data for 3,948 participants came from the Colombo Twin and Singleton Follow-up Study (CoTaSS-2). Using self-report measures of depressive symptoms and HRQL, we conducted univariate and bivariate sex-limitation twin a"],"journal":["PloS one"],"pubmed_title":["The aetiological relationship between depressive symptoms and health-related quality of life: A population-based twin study in Sri Lanka."],"pmcid":["PMC8967029"],"funding_grant_id":["093206/Z/10/Z"],"pubmed_authors":["Nas Z","Siribaddana SH","Sumathipala A","Rijsdijk FV","Triantafyllou P","Hotopf M","Ritchie SJ","Zavos HMS","Jayaweera K"],"additional_accession":[]},"is_claimable":false,"name":"The aetiological relationship between depressive symptoms and health-related quality of life: A population-based twin study in Sri Lanka.","description":"<h4>Objective</h4>Depression often co-occurs with poor health-related quality of life (HRQL). Twin studies report genetic and individual-level environmental underpinnings in the aetiology of both depression and HRQL, but there is limited twin research exploring this association further. There is also little evidence on sex differences and non-Western populations are underrepresented. In this paper we explored the phenotypic and aetiological relationship between depressive symptoms and HRQL and possible sex differences in a low-middle-income Sri Lankan population.<h4>Method</h4>Data for 3,948 participants came from the Colombo Twin and Singleton Follow-up Study (CoTaSS-2). Using self-report measures of depressive symptoms and HRQL, we conducted univariate and bivariate sex-limitation twin a","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-26T15:18:14.069Z","creation":"2025-04-06T14:50:22.841Z"},"accession":"S-EPMC8967029","cross_references":{"pubmed":["35353839"],"doi":["10.1371/journal.pone.0265421"]}}