{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Klomp A"],"funding":["NIMH NIH HHS","NINDS NIH HHS","National Institutes of Health"],"pagination":["e0263197"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8967030"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(3)"],"pubmed_abstract":["Voltage-gated Ca2+ channels are critical for the development and mature function of the nervous system. Variants in the CACNA2D4 gene encoding the α2δ-4 auxiliary subunit of these channels are associated with neuropsychiatric and neurodevelopmental disorders. α2δ-4 is prominently expressed in the retina and is crucial for vision, but extra-retinal functions of α2δ-4 have not been investigated. Here, we sought to fill this gap by analyzing the behavioral phenotypes of α2δ-4 knockout (KO) mice. α2δ-4 KO mice (both males and females) exhibited significant impairments in prepulse inhibition that were unlikely to result from the modestly elevated auditory brainstem response thresholds. Whereas α2δ-4 KO mice of both sexes were hyperactive in various assays, only females showed impaired motor coo"],"journal":["PloS one"],"pubmed_title":["The voltage-gated Ca2+ channel subunit α2δ-4 regulates locomotor behavior and sensorimotor gating in mice."],"pmcid":["PMC8967030"],"funding_grant_id":["EY026817","DC017955","NS075599","DC012049","R01 MH116043","NS113189","NS115653","R01 NS125884","R03 NS115653","MH116043","DC002842","R01 NS075599","R01 NS113189"],"pubmed_authors":["Usachev YM","Lee A","Russo AF","Narayanan NS","Klomp A","Smith RJ","Iwasa Y","Omichi R"],"additional_accession":[]},"is_claimable":false,"name":"The voltage-gated Ca2+ channel subunit α2δ-4 regulates locomotor behavior and sensorimotor gating in mice.","description":"Voltage-gated Ca2+ channels are critical for the development and mature function of the nervous system. Variants in the CACNA2D4 gene encoding the α2δ-4 auxiliary subunit of these channels are associated with neuropsychiatric and neurodevelopmental disorders. α2δ-4 is prominently expressed in the retina and is crucial for vision, but extra-retinal functions of α2δ-4 have not been investigated. Here, we sought to fill this gap by analyzing the behavioral phenotypes of α2δ-4 knockout (KO) mice. α2δ-4 KO mice (both males and females) exhibited significant impairments in prepulse inhibition that were unlikely to result from the modestly elevated auditory brainstem response thresholds. Whereas α2δ-4 KO mice of both sexes were hyperactive in various assays, only females showed impaired motor coo","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-26T15:15:43.365Z","creation":"2025-04-06T14:52:34.249Z"},"accession":"S-EPMC8967030","cross_references":{"pubmed":["35353835"],"doi":["10.1371/journal.pone.0263197"]}}