biostudies-literatureBenatar MBrain Research UKNIA NIH HHSThe ALS AssociationMedical Research CouncilNational Institute for Health Research (NIHR)Motor Neurone Disease AssociationNINDS NIH HHSNational Institutes of HealthThe Muscular Dystrophy AssociationThe Motor Neurone Disease AssociationThe Association for Frontotemporal Degeneration, Biogen and AveXis27-44https://www.ebi.ac.uk/biostudies/studies/S-EPMC8967095biostudies-literatureUnknown145(1)Significant progress has been made in understanding the pre-symptomatic phase of amyotrophic lateral sclerosis. While much is still unknown, advances in other neurodegenerative diseases offer valuable insights. Indeed, it is increasingly clear that the well-recognized clinical syndromes of Alzheimer's disease, Parkinson's disease, Huntington's disease, spinal muscular atrophy and frontotemporal dementia are also each preceded by a pre-symptomatic or prodromal period of varying duration, during which the underlying disease process unfolds, with associated compensatory changes and loss of inherent system redundancy. Key insights from these diseases highlight opportunities for discovery in amyotrophic lateral sclerosis. The development of biomarkers reflecting amyloid and tau has led to a shiBrain : a journal of neurologyPreventing amyotrophic lateral sclerosis: insights from pre-symptomatic neurodegenerative diseases.PMC8967095NIHR202421U54 NS092091MR/M023664/1MR/J009482/1P30 AG062677ALCHALABI-TALBOT/APR14/926-794U01 AG006786P01 AG019724MR/L501529/1TURNER/OCT18/989-797R01 NS105479MR/M008525/1MR/T046015/1G0600974TURNER/JAN13/944-795ALCHALABI-DOBSON/APR14/829-791MR/R024804/1202021-32Al-Chalabi/Apr19/870-791Lee SThakur NBenatar MMcMillan CTPostuma RBStanislaw CLe Ber IGendron TMcHutchison CAndersen PMRoss CATurner MFloeter MKGubitz ABoeve BFCosentino SFirst International Pre-Symptomatic ALS WorkshopRohrer JArias JJAbrahams SGrignon ALRoss CDave KWuu JBoeve BFradette SMalaspina AMcMillan CShefner JRohrer JDGranit VArias JNicholson KTurner MRFerguson TRosen HRobinson RFinkel RSWeishaupt JKaufman PGrossman MTatton NMcDermott MPAl-Chalabi APostuma RPetersen RfalsePreventing amyotrophic lateral sclerosis: insights from pre-symptomatic neurodegenerative diseases.Significant progress has been made in understanding the pre-symptomatic phase of amyotrophic lateral sclerosis. While much is still unknown, advances in other neurodegenerative diseases offer valuable insights. Indeed, it is increasingly clear that the well-recognized clinical syndromes of Alzheimer's disease, Parkinson's disease, Huntington's disease, spinal muscular atrophy and frontotemporal dementia are also each preceded by a pre-symptomatic or prodromal period of varying duration, during which the underlying disease process unfolds, with associated compensatory changes and loss of inherent system redundancy. Key insights from these diseases highlight opportunities for discovery in amyotrophic lateral sclerosis. The development of biomarkers reflecting amyloid and tau has led to a shi2022-01-01T00:00:00Z2022 Mar2025-04-05T15:59:33.958Z2025-04-05T15:59:33.958ZS-EPMC89670953467760610.1093/brain/awab404