{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Folsche V"],"pubmed_abstract":["Plant tetrapyrrole biosynthesis (TPS) provides the indispensable chlorophyll (Chl) and heme molecules in photosynthetic organisms. Post-translational mechanisms control the enzymes to ensure a balanced flow of intermediates in the pathway and synthesis of appropriate amounts of both endproducts. One of the critical regulators of TPS is GENOMES UNCOUPLED 4 (GUN4). GUN4 interacts with magnesium chelatase (MgCh), and its binding of the catalytic substrate and product of the MgCh reaction stimulates the insertion of Mg<sup>2+</sup> into protoporphyrin IX. Despite numerous <i>in vitro</i> studies, knowledge about the <i>in vivo</i> function of the GUN4:porphyrin interaction for the whole TPS pathway, particularly in plants, is still limited. To address this, we focused on two highly conserved a"],"journal":["Frontiers in plant science"],"pagination":["850504"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8967248"],"repository":["biostudies-literature"],"pubmed_title":["Impact of Porphyrin Binding to GENOMES UNCOUPLED 4 on Tetrapyrrole Biosynthesis <i>in planta</i>."],"pmcid":["PMC8967248"],"pubmed_authors":["Großmann C","Richter AS","Folsche V"],"additional_accession":[]},"is_claimable":false,"name":"Impact of Porphyrin Binding to GENOMES UNCOUPLED 4 on Tetrapyrrole Biosynthesis <i>in planta</i>.","description":"Plant tetrapyrrole biosynthesis (TPS) provides the indispensable chlorophyll (Chl) and heme molecules in photosynthetic organisms. Post-translational mechanisms control the enzymes to ensure a balanced flow of intermediates in the pathway and synthesis of appropriate amounts of both endproducts. One of the critical regulators of TPS is GENOMES UNCOUPLED 4 (GUN4). GUN4 interacts with magnesium chelatase (MgCh), and its binding of the catalytic substrate and product of the MgCh reaction stimulates the insertion of Mg<sup>2+</sup> into protoporphyrin IX. Despite numerous <i>in vitro</i> studies, knowledge about the <i>in vivo</i> function of the GUN4:porphyrin interaction for the whole TPS pathway, particularly in plants, is still limited. To address this, we focused on two highly conserved a","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-26T15:16:10.29Z","creation":"2025-04-06T14:53:17.004Z"},"accession":"S-EPMC8967248","cross_references":{"pubmed":["35371166"],"doi":["10.3389/fpls.2022.850504"]}}