biostudies-literatureUnknown9Graziadei GSickle cell disease (SCD) is a worldwide distributed hereditary red cell disorder characterized by recurrent acute vaso-occlusive crises (VOCs and anemia). Gold standard treatments are hydroxycarbamide (HC) and/or different red blood cell (RBC) transfusion regimens to limit disease progression. Here, we report a retrospective study on 1,579 SCD patients (median age 23 years; 802 males/777 females), referring to 34 comprehensive Italian centers for hemoglobinopathies. Although we observed a similar proportion of Caucasian (47.9%) and African (48.7%) patients, Italian SCD patients clustered into two distinct overall groups: children of African descent and adults of Caucasian descent. We found a subset of SCD patients requiring more intensive therapy with a combination of HC plus chronic tranFrontiers in medicine832154https://www.ebi.ac.uk/biostudies/studies/S-EPMC8967327biostudies-literatureTransfusional Approach in Multi-Ethnic Sickle Cell Patients: Real-World Practice Data From a Multicenter Survey in Italy.PMC8967327Casale MPalazzi GMacchi SRossi ERusso GDi Maggio RLisi RFilosa AVoi VDe Franceschi LBonetti FPiperno AForni GLFacchini EColombatti RGiona FBadalamenti LArcioni FVassanelli AMaroni PGiordano PGraziadei GSau AMarktel SMurgia MMasera NVenturelli DOriga RBortolotti MCorti PBonomo PMariani RColarusso GGianesin BQuota ANotarangelo LDCampisi SPinto VMLodi GAllo MRosso RBoscarol GLongo FD'Ascola DFidone CPiel FBSainati LRigano PfalseTransfusional Approach in Multi-Ethnic Sickle Cell Patients: Real-World Practice Data From a Multicenter Survey in Italy.Sickle cell disease (SCD) is a worldwide distributed hereditary red cell disorder characterized by recurrent acute vaso-occlusive crises (VOCs and anemia). Gold standard treatments are hydroxycarbamide (HC) and/or different red blood cell (RBC) transfusion regimens to limit disease progression. Here, we report a retrospective study on 1,579 SCD patients (median age 23 years; 802 males/777 females), referring to 34 comprehensive Italian centers for hemoglobinopathies. Although we observed a similar proportion of Caucasian (47.9%) and African (48.7%) patients, Italian SCD patients clustered into two distinct overall groups: children of African descent and adults of Caucasian descent. We found a subset of SCD patients requiring more intensive therapy with a combination of HC plus chronic tran2022-01-01T00:00:00Z20222026-04-08T18:11:01.955Z2025-04-05T22:19:50.994ZS-EPMC89673273537239310.3389/fmed.2022.832154