{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Norrish G"],"funding":["Career Development Fellowship","University College London Hospitals","British Heart Foundation","UK Department of Health’s","Medical Research Council Clinical","University College London","NHMRC","National Institutes of Health","Clinical Academic Research Partnership","Myokardia, Inc","Great Ormond Street Hospital Childrens Charity","Max’s Foundation and Great Ormond Street Hospital Children’s Charity","Medical Research Council","National Institute for Health Research Biomedical Research Centres","National Institute for Health Research (NIHR)","National Health and Medical Research Council"],"pagination":["678-686"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8967478"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["29(4)"],"pubmed_abstract":["<h4>Aims</h4>Sudden cardiac death (SCD) is the most common mode of death in childhood hypertrophic cardiomyopathy (HCM). The newly developed HCM Risk-Kids model provides clinicians with individualized estimates of risk. The aim of this study was to externally validate the model in a large independent, multi-centre patient cohort.<h4>Methods and results</h4>A retrospective, longitudinal cohort of 421 patients diagnosed with HCM aged 1-16 years independent of the HCM Risk-Kids development and internal validation cohort was studied. Data on HCM Risk-Kids predictor variables (unexplained syncope, non-sustained ventricular tachycardia, maximal left ventricular wall thickness, left atrial diameter, and left ventricular outflow tract gradient) were collected from the time of baseline clinical eva"],"journal":["European journal of preventive cardiology"],"pubmed_title":["External validation of the HCM Risk-Kids model for predicting sudden cardiac death in childhood hypertrophic cardiomyopathy."],"pmcid":["PMC8967478"],"funding_grant_id":["NIHR200158","FS/16/72/32270","W1135","#1162929","#1154992","MR/T024062/1"],"pubmed_authors":["Qu C","Khraiche D","Yamazawa H","Ingles J","Helms A","Colan S","Elliott PM","Ojala TH","Omar RZ","Cervi E","Marrone C","Schouvey S","Field E","Centeno F","Saberi S","Ho CY","Day SM","Sinagra G","Norrish G","Rossano J","Kaski JP","Klaassen S","Russell M","Semsarian C","Popoiu A","Olivotto I","Wittekind SG"],"additional_accession":[]},"is_claimable":false,"name":"External validation of the HCM Risk-Kids model for predicting sudden cardiac death in childhood hypertrophic cardiomyopathy.","description":"<h4>Aims</h4>Sudden cardiac death (SCD) is the most common mode of death in childhood hypertrophic cardiomyopathy (HCM). The newly developed HCM Risk-Kids model provides clinicians with individualized estimates of risk. The aim of this study was to externally validate the model in a large independent, multi-centre patient cohort.<h4>Methods and results</h4>A retrospective, longitudinal cohort of 421 patients diagnosed with HCM aged 1-16 years independent of the HCM Risk-Kids development and internal validation cohort was studied. Data on HCM Risk-Kids predictor variables (unexplained syncope, non-sustained ventricular tachycardia, maximal left ventricular wall thickness, left atrial diameter, and left ventricular outflow tract gradient) were collected from the time of baseline clinical eva","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2026-06-07T03:22:54.75Z","creation":"2025-04-19T12:55:44.473Z"},"accession":"S-EPMC8967478","cross_references":{"pubmed":["34718528"],"doi":["10.1093/eurjpc/zwab181"]}}