biostudies-literatureUnknown3(2)Seethapathy RGilead Sciences<h4>Background</h4>Remdesivir is not currently approved for patients with eGFR <30 ml/min per 1.73 m². We aimed to determine the safety of remdesivir in patients with kidney failure.<h4>Methods</h4>This study was a retrospective cohort study of patients with COVID-19 hospitalized between May 2020 and January 2021 with eGFR <30 ml/min per 1.73 m² who received remdesivir and historical controls with COVID-19 hospitalized between March 1, 2020 and April 30, 2020 prior to the emergency use authorization of remdesivir within a large health care system. Patients were 1:1 matched by propensity scores accounting for factors associated with treatment assignment. Adverse events and hospital outcomes were recorded by manual chart review.<h4>Results</h4>The overall cohort includeKidney360269-278https://www.ebi.ac.uk/biostudies/studies/S-EPMC8967642biostudies-literatureA Propensity Score-Matched Observational Study of Remdesivir in Patients with COVID-19 and Severe Kidney Disease.PMC8967642Zhao SSise MESeethapathy RStrohbehn IALong JDfalseA Propensity Score-Matched Observational Study of Remdesivir in Patients with COVID-19 and Severe Kidney Disease.<h4>Background</h4>Remdesivir is not currently approved for patients with eGFR <30 ml/min per 1.73 m². We aimed to determine the safety of remdesivir in patients with kidney failure.<h4>Methods</h4>This study was a retrospective cohort study of patients with COVID-19 hospitalized between May 2020 and January 2021 with eGFR <30 ml/min per 1.73 m² who received remdesivir and historical controls with COVID-19 hospitalized between March 1, 2020 and April 30, 2020 prior to the emergency use authorization of remdesivir within a large health care system. Patients were 1:1 matched by propensity scores accounting for factors associated with treatment assignment. Adverse events and hospital outcomes were recorded by manual chart review.<h4>Results</h4>The overall cohort include2022-01-01T00:00:00Z2022 Feb2025-04-04T12:57:49.305Z2025-04-04T12:57:49.305ZS-EPMC89676423537312510.34067/kid.000615202110.34067/KID.0006152021