biostudies-literatureEveleens Maarse BCSwedish Medical AssociationNjurfondenNIA NIH HHSDutch Kidney FoundationNational Institute for Health Research (NIHR)European Renal AssociationStockholm County Council786-797https://www.ebi.ac.uk/biostudies/studies/S-EPMC8967670biostudies-literatureUnknown15(4)<h4>Background</h4>Depressive symptoms are associated with adverse clinical outcomes in patients with end-stage kidney disease; however, few small studies have examined this association in patients with earlier phases of chronic kidney disease (CKD). We studied associations between baseline depressive symptoms and clinical outcomes in older patients with advanced CKD and examined whether these associations differed depending on sex.<h4>Methods</h4>CKD patients (≥65 years; estimated glomerular filtration rate ≤20 mL/min/1.73 m²) were included from a European multicentre prospective cohort between 2012 and 2019. Depressive symptoms were measured by the five-item Mental Health Inventory (cut-off ≤70; 0-100 scale). Cox proportional hazard analysis was used to study associations betwClinical kidney journalAssociations between depressive symptoms and disease progression in older patients with chronic kidney disease: results of the EQUAL study.PMC8967670SB142P30 AG059307Russo DTognarelli GChesnaye NCPozzi CMotta DMcNally HCiurlino DGaillard CNeumeier KMcKeever AGlowski DStephan TWanner CBaragetti IMalaguti MRoderick PJager KJKooman JEveleens Maarse BCMagnano MSchulz PCaskey FJRanghino ANavjee SLeimbach TCappellaio FCicchetti THeimburger OFerraro ANigro RHahn KMcGlynn DMele ABahner USchouten RBerger SNowanska KUllah ANaujoks HRothele JGambaro GRenker SBoero RDurlik MTorp AStucchi ARoy GTurner JPerras BStendahl MManan SLuisa Sirico MWong JDe Simone WJager KO'Toole CSchrander AAcampora PMangano SZullo CMarx CIchtiaris PRogland BTsalouichos ACosaro ACockwell PMeuleman YKalra PBlom ALMusiala AMazur JBoom HRaasveld MEijgenraam JWTorino CFrischmuth ND'alessandro CBlaser Cvan Diepen MKashioulis PEvans MOlczyk EMaffei SBascaran Hernandez IDekker FWVervloet MBoots JSchlee IMurtagh HSchlee HBorrelli SPani AMiskowiec-Wisniewska IWeinreich TWilkinson LSundelin FKrieter DSavoldi SSagliocca ANieszporek TAntonio BStovesand TJones KPostorino MEmde CToscano GWoodman ARappa TBanda JSummersgill CMasri-Senghor HBeerenhout CRotmans JGeddes CVerburgh CFerraresi MKrajewska MBertoli SBlouin KSiegert CJensen USands DWilcox JAnsali FGesualdo LDrechsler CCaloro GSchmidt-Gurtler HScarpioni RProvenzano MGrontoft KCSvensson MBergamo DDe Blasio Avan Dam BWeetman MPalm SAugustyniak-Bartosik HCrosbie SCasar SRaffaele Di Iorio BEQUAL Study InvestigatorsBiancone LHoogeveen EMaxia SBonforte GDi Bari MDelrieux SJoinson MMatthews MHeidenreich SKuan YBiribauer SGiacchino FDutton MRayner HBigatti GPondel JAbaterusso CSeeger WDattolo PSchmiedeke Tvan Buren MVogt LWuttke NMason PIwig BAign SBeige JBos WJWRicardi MVigotti FMarinangeli GManitius JPalmieri NPorto GCaskey FHaydock LSajith RHarron CPizzarelli FHirst GBleakley Nvan Esch SAlessandra BPalazzo VConte GVargas DSchneider AConte FKirste PCupisti AFavaro ECirillo PHopf MLaudato MCapizzi IMalandra RGreco GJanmaat CMichels WMPignataro AAlmquist TBlankestijn PDel Rosso GLeurs POldrizzi LNaticchia AWelander GMelander SSicoli RBoorsma SJedrzejak KAydin ZCabiddu GVoskamp PJonsson AKonings CDekker FUhlin FAnding-Rost KDimeny ESchramm LChesnaye NPiccoli GSchattel SBarrett CNowak LFumagalli GPlaten EMathavakkannan SSchwedler SMurrone PHeleniak ZCarmody MCianciotta FSzymczak MCapasso GIrmler EKing HSomma CSzymczak AMcLaren BWallquist CBerdeprado JHoorn EChapman SDorota SRoser SFuchs DMorgan NBrown STickle SfalseAssociations between depressive symptoms and disease progression in older patients with chronic kidney disease: results of the EQUAL study.<h4>Background</h4>Depressive symptoms are associated with adverse clinical outcomes in patients with end-stage kidney disease; however, few small studies have examined this association in patients with earlier phases of chronic kidney disease (CKD). We studied associations between baseline depressive symptoms and clinical outcomes in older patients with advanced CKD and examined whether these associations differed depending on sex.<h4>Methods</h4>CKD patients (≥65 years; estimated glomerular filtration rate ≤20 mL/min/1.73 m²) were included from a European multicentre prospective cohort between 2012 and 2019. Depressive symptoms were measured by the five-item Mental Health Inventory (cut-off ≤70; 0-100 scale). Cox proportional hazard analysis was used to study associations betw2022-01-01T00:00:00Z2022 Apr2026-03-15T19:49:53.435Z2025-04-05T15:53:10.033ZS-EPMC89676703537144010.1093/ckj/sfab261