{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhao Q"],"funding":["NIDDK NIH HHS","NHLBI NIH HHS"],"pagination":["878-884"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8967724"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["603(7903)"],"pubmed_abstract":["Interoception, the ability to timely and precisely sense changes inside the body, is critical for survival<sup>1-4</sup>. Vagal sensory neurons (VSNs) form an important body-to-brain connection, navigating visceral organs along the rostral-caudal axis of the body and crossing the surface-lumen axis of organs into appropriate tissue layers<sup>5,6</sup>. The brain can discriminate numerous body signals through VSNs, but the underlying coding strategy remains poorly understood. Here we show that VSNs code visceral organ, tissue layer and stimulus modality-three key features of an interoceptive signal-in different dimensions. Large-scale single-cell profiling of VSNs from seven major organs in mice using multiplexed projection barcodes reveals a 'visceral organ' dimension composed of differen"],"journal":["Nature"],"pubmed_title":["A multidimensional coding architecture of the vagal interoceptive system."],"pmcid":["PMC8967724"],"funding_grant_id":["DP2 HL151354","R01 HL150449","K01 DK113047"],"pubmed_authors":["Xu QJ","Chang RB","Wang R","Zhao Q","Dai Pra R","Zhang L","Yu CD"],"additional_accession":[]},"is_claimable":false,"name":"A multidimensional coding architecture of the vagal interoceptive system.","description":"Interoception, the ability to timely and precisely sense changes inside the body, is critical for survival<sup>1-4</sup>. Vagal sensory neurons (VSNs) form an important body-to-brain connection, navigating visceral organs along the rostral-caudal axis of the body and crossing the surface-lumen axis of organs into appropriate tissue layers<sup>5,6</sup>. The brain can discriminate numerous body signals through VSNs, but the underlying coding strategy remains poorly understood. Here we show that VSNs code visceral organ, tissue layer and stimulus modality-three key features of an interoceptive signal-in different dimensions. Large-scale single-cell profiling of VSNs from seven major organs in mice using multiplexed projection barcodes reveals a 'visceral organ' dimension composed of differen","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-04-04T14:57:04.031Z","creation":"2024-11-20T05:54:06.548Z"},"accession":"S-EPMC8967724","cross_references":{"pubmed":["35296859"],"doi":["10.1038/s41586-022-04515-5"]}}