biostudies-literatureVanderWalde NNational Cancer InstituteNCI NIH HHS294-301https://www.ebi.ac.uk/biostudies/studies/S-EPMC8967782biostudies-literatureUnknown13(3)<h4>Purpose</h4>Expected toxicity from chemoradiation (CRT) is an important factor in treatment decisions but is poorly understood in older adults with lower gastrointestinal (GI) malignancies. Our objective was to compare acute adverse events (AAEs) of older and younger adults with lower GI malignancies treated on NRG studies.<h4>Methods</h4>Data from 6 NRG trials, testing combined modality therapy in patients with anal or rectal cancer, were used to test the hypothesis that older age was associated with increased AAEs. AAEs and compliance with protocol-directed therapy were compared between patients aged ≥70 and < 70. Categorical variables were compared across age groups using the chi-square test. The association of age on AAEs was evaluated using a covariate-adjusted logistic regressionJournal of geriatric oncologyThe association of age with acute toxicities in NRG oncology combined modality lower GI cancer trials.PMC8967782UG1 CA189867UG1 CA233290P30 CA008748U10 CA180868U10 CA180822Lichtman SMBerger AArora ALee RJVanderWalde AEllsworth SGKachnic LMeyer JCrane CHJagsi RVanderWalde NMoughan JGreen NHopkins JLMeropol NJAnne RBallo MAjani JMohiuddin MfalseThe association of age with acute toxicities in NRG oncology combined modality lower GI cancer trials.<h4>Purpose</h4>Expected toxicity from chemoradiation (CRT) is an important factor in treatment decisions but is poorly understood in older adults with lower gastrointestinal (GI) malignancies. Our objective was to compare acute adverse events (AAEs) of older and younger adults with lower GI malignancies treated on NRG studies.<h4>Methods</h4>Data from 6 NRG trials, testing combined modality therapy in patients with anal or rectal cancer, were used to test the hypothesis that older age was associated with increased AAEs. AAEs and compliance with protocol-directed therapy were compared between patients aged ≥70 and < 70. Categorical variables were compared across age groups using the chi-square test. The association of age on AAEs was evaluated using a covariate-adjusted logistic regression2022-01-01T00:00:00Z2022 Apr2025-04-22T11:49:27.963Z2025-04-06T00:07:15.096ZS-EPMC89677823475649610.1016/j.jgo.2021.10.008