{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Goncalves J"],"funding":["Office of Research Infrastructure Programs, National Institutes of Health","Howard Hughes Medical Institute","National Institutes of Health"],"pagination":["104082"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8968053"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["25(4)"],"pubmed_abstract":["Regulated metabolism is required for behaviors as adults age. To understand how lipid usage affects motor coordination, we studied male <i>Caenorhabditis elegans</i> copulation as a model of energy-intensive behavior. Copulation performance drops after 48 h of adulthood. We found that 12-24 h before behavioral decline, males prioritize exploring and copulation behavior over feeding, suggesting that catabolizing stored metabolites, such as lipids, occurs during this period. Because <i>fat-6/7</i>-encoded stearoyl-CoA desaturases are essential for converting the ingested fatty acids to lipid storage, we examined the copulation behavior and neural calcium transients of <i>fat-6</i>(<i>lf</i>)<i>; fat-7</i>(<i>lf</i>) mutants. In wild-type males, intestinal and epithelial <i>fat-6/7</i> expression increases during the first 48 h of adulthood. The <i>fat-6</i>(<i>lf</i>)<i>; fat-7</i>(<i>lf</i>) behavioral and metabolic defects indicate that in aging wild-type males, the increased expression of stearoyl-CoA desaturases in the epidermis may indirectly modulate the levels of EAG-family K<sup>+</sup> channels in the reproductive cholinergic neurons and muscles."],"journal":["iScience"],"pubmed_title":["Stearoyl-CoA desaturases sustain cholinergic excitation and copulatory robustness in metabolically aging <i>C. elegans</i>males."],"pmcid":["PMC8968053"],"funding_grant_id":["P40OD010440"],"pubmed_authors":["Goncalves J","Garcia LR","Wan Y"],"additional_accession":[]},"is_claimable":false,"name":"Stearoyl-CoA desaturases sustain cholinergic excitation and copulatory robustness in metabolically aging <i>C. elegans</i>males.","description":"Regulated metabolism is required for behaviors as adults age. To understand how lipid usage affects motor coordination, we studied male <i>Caenorhabditis elegans</i> copulation as a model of energy-intensive behavior. Copulation performance drops after 48 h of adulthood. We found that 12-24 h before behavioral decline, males prioritize exploring and copulation behavior over feeding, suggesting that catabolizing stored metabolites, such as lipids, occurs during this period. Because <i>fat-6/7</i>-encoded stearoyl-CoA desaturases are essential for converting the ingested fatty acids to lipid storage, we examined the copulation behavior and neural calcium transients of <i>fat-6</i>(<i>lf</i>)<i>; fat-7</i>(<i>lf</i>) mutants. In wild-type males, intestinal and epithelial <i>fat-6/7</i> expression increases during the first 48 h of adulthood. The <i>fat-6</i>(<i>lf</i>)<i>; fat-7</i>(<i>lf</i>) behavioral and metabolic defects indicate that in aging wild-type males, the increased expression of stearoyl-CoA desaturases in the epidermis may indirectly modulate the levels of EAG-family K<sup>+</sup> channels in the reproductive cholinergic neurons and muscles.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2025-04-27T01:11:16.177Z","creation":"2025-04-06T18:08:00.998Z"},"accession":"S-EPMC8968053","cross_references":{"pubmed":["35372802"],"doi":["10.1016/j.isci.2022.104082"]}}