{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["38(3)"],"submitter":["Al-Kouatly HB"],"pubmed_abstract":["It is unknown whether antiretroviral (ARV) drugs in women living with HIV (WLHIV) are associated with mitochondrial toxicity and altered fat oxidation and branched-chain amino acid metabolism in the placenta and fetus. Immediately after delivery, we froze placental biopsies from 20 WLHIV and 20 matched uninfected women. We analyzed global biochemical profiles using high-performance liquid chromatography/tandem mass spectrometry and gas chromatography/mass spectrometry. We used <i>t</i>-tests, principle component analysis, hierarchical clustering, and random forest analysis (RFA) in our analysis. Twelve WLHIV were on protease inhibitors, six on non-nucleoside reverse inhibitors, and two on integrase strand inhibitors with optimized backbone. Mean birth weight of HIV-exposed neonates was sig"],"journal":["AIDS research and human retroviruses"],"pagination":["198-207"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8968831"],"repository":["biostudies-literature"],"pubmed_title":["Metabolomics in Placental Tissue from Women Living with HIV."],"pmcid":["PMC8968831"],"pubmed_authors":["Al-Kouatly HB","Inagaki K","Scott RK","Cunningham G","Rakhmanina N","Visclosky T","Ingram BO","Kirmse B","Makhamreh MM"],"additional_accession":[]},"is_claimable":false,"name":"Metabolomics in Placental Tissue from Women Living with HIV.","description":"It is unknown whether antiretroviral (ARV) drugs in women living with HIV (WLHIV) are associated with mitochondrial toxicity and altered fat oxidation and branched-chain amino acid metabolism in the placenta and fetus. Immediately after delivery, we froze placental biopsies from 20 WLHIV and 20 matched uninfected women. We analyzed global biochemical profiles using high-performance liquid chromatography/tandem mass spectrometry and gas chromatography/mass spectrometry. We used <i>t</i>-tests, principle component analysis, hierarchical clustering, and random forest analysis (RFA) in our analysis. Twelve WLHIV were on protease inhibitors, six on non-nucleoside reverse inhibitors, and two on integrase strand inhibitors with optimized backbone. Mean birth weight of HIV-exposed neonates was sig","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-04-04T21:44:05.811Z","creation":"2025-04-04T21:44:05.811Z"},"accession":"S-EPMC8968831","cross_references":{"pubmed":["34498948"],"doi":["10.1089/aid.2021.0056","10.1089/AID.2021.0056"]}}